UFD1 and UBXN6

Data Source:
BioGRID (pull down)

		UFD1	UBXN6
Description		ubiquitin recognition factor in ER associated degradation 1	UBX domain protein 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex	Nucleus Cytoplasm Lysosomal Membrane Endosome Microtubule Organizing Center Cytosol Extrinsic Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding	Protein Binding
	Biological Process	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process	Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways		Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS			Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)
Interacting Genes		23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP	20 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 PLEKHB2 SMURF1 SUSD6 SVIP TRIM39 UBC UBXN10 UBXN2A UBXN2B UFD1 VCP YOD1
Entrez ID		7353	80700
HPRD ID		06778	18253
Ensembl ID		ENSG00000070010	ENSG00000167671
Uniprot IDs		Q541A5 Q92890	Q9BZV1
PDB IDs		2YUJ 5B6C 5C1B	6SAP
Enriched GO Terms of Interacting Partners?
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