C9 and C8A

Data Source:
HPRD (in vitro)

		C9	C8A
Description		complement C9	complement C8 alpha chain
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle	Extracellular Region Membrane Attack Complex Extracellular Space Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Protein Binding	Complement Binding Protein Binding Protein-containing Complex Binding
	Biological Process	Cell Killing Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation Protein Homooligomerization	Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cytolysis Regulation Of Complement Activation
Pathways		Terminal pathway of complement Regulation of Complement cascade	Terminal pathway of complement Regulation of Complement cascade
Drugs		Copper	Zinc Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488) Chronic kidney disease ( 20383146) Health literacy ( 31250787) Systemic lupus erythematosus ( 19838195)	Blood protein levels ( 28240269)
Interacting Genes		4 interacting genes: C8A CD59 CLU LAMTOR5	9 interacting genes: C8B C8G C9 CD59 GOLT1A GPR152 MMGT1 SLC10A1 SLC7A1
Entrez ID		735	731
HPRD ID		00408	00409
Ensembl ID		ENSG00000113600	ENSG00000157131
Uniprot IDs		P02748	P07357
PDB IDs		5FMW 6DLW 6H03 6H04	2QOS 2QQH 2RD7 3OJY 6H03 6H04
Enriched GO Terms of Interacting Partners?
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