UBE2E2 and PGPEP1

Data Source:
BioGRID (two hybrid)

		UBE2E2	PGPEP1
Description		ubiquitin conjugating enzyme E2 E2	pyroglutamyl-peptidase I
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Pyroglutamyl-peptidase Activity
	Biological Process	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Protein Phosphopantetheinylation ISG15-protein Conjugation Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Proteolysis
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Asthma ( 32296059) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Hematocrit ( 32888494) Hemoglobin ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolite levels ( 23823483) Motion sickness ( 25628336) Physiological dysregulation (Mahalanobis distance) ( 32235003) Psychosis (atypical) ( 24132900) Red blood cell count ( 32888494) RR interval (tricyclic/tetracyclic antidepressant use interaction) ( 28039329) Seasonality and depression ( 30217971) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 23945395 32499647 30718926 28869590) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 27918534) Visceral adipose tissue/subcutaneous adipose tissue ratio adjusted for BMI ( 27918534) Vitiligo ( 27723757)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 26961502 28892062 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronotype ( 30696823) Coronary artery disease ( 29212778) Gastroesophageal reflux disease ( 31527586) Growth differentiation factor-15 levels ( 29628937 22997280) Growth differentiation factor-15 levels (conditioned on rs888663) ( 29628937) Hand grip strength ( 29691431) Medication use (beta blocking agents) ( 31015401) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Periodontitis (Mean PAL) ( 24024966) Systemic lupus erythematosus ( 26606652)
Interacting Genes		75 interacting genes: APP ARIH1 ARIH2 ARRDC3 ASXL2 BARD1 BRCA1 CBL CHFR CUEDC1 CUL3 CUL9 DAZAP2 DTX3 DTX3L DZIP3 FAM9B IPO11 ITCH MARCHF3 MDM2 MID1 MID2 MKRN3 MUL1 NEDD4L NFE2L2 OTUB1 PCGF2 PDLIM2 PGPEP1 PRAM1 PRKN RBX1 RC3H2 RING1 RLIM RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF125 RNF126 RNF14 RNF166 RNF185 RNF19A RNF2 RNF25 RNF31 RNF4 RNF5 RNF8 SRPK1 SRPK2 STUB1 TRIM2 TRIM23 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 UBA1 UBOX5 WWP2 XIAP ZNRF1	4 interacting genes: AQP1 NTAQ1 UBE2E2 UBE2E3
Entrez ID		7325	54858
HPRD ID		06779	07141
Ensembl ID		ENSG00000182247	ENSG00000130517
Uniprot IDs		Q96LR5	Q9NXJ5 S4R2Y9 U3KQ24
PDB IDs		1Y6L 6W9A
Enriched GO Terms of Interacting Partners?
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