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UBC and CCDC50
Data Source:
BioGRID
(pull down, pull down)
UBC
CCDC50
Description
ubiquitin C
coiled-coil domain containing 50
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Endocytic Vesicle Membrane
Vesicle
Host Cell
Extracellular Exosome
Cytosol
Molecular Function
Protease Binding
RNA Binding
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPK Activity
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Protein Targeting To Peroxisome
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Wnt Signaling Pathway
Endosomal Transport
Protein Ubiquitination
Protein Deubiquitination
Viral Life Cycle
Virion Assembly
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
Translesion Synthesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Nucleotide-excision Repair, DNA Incision
TRIF-dependent Toll-like Receptor Signaling Pathway
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Transmembrane Transport
Membrane Organization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Error-free Translesion Synthesis
Intracellular Transport Of Virus
Sensory Perception Of Sound
Pathways
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
Circadian Clock
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Maturation of protein E
Maturation of protein E
Negative regulation of FLT3
FLT3 signaling by CBL mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
N-Formylmethionine
Diseases
GWAS
HDL cholesterol levels (
30698716
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
High density lipoprotein cholesterol levels (
29403010
)
Total cholesterol levels (
29403010
)
Alzheimer's disease biomarkers (
23562540
)
Lung cancer in never smokers (
28604730
)
Interacting Genes
647 interacting genes:
ABCB7
ABL1
ABRAXAS1
ABRAXAS2
ACTA1
ACTC1
ACTL8
ADH7
ADRM1
AGO2
AGRN
AGTPBP1
ALG1
AMFR
AMPH
ANAPC1
ANAPC11
ANAPC2
ANAPC7
ANGPTL3
ANKIB1
ANKRD13A
ANKRD13B
ANKRD13D
ANKRD30A
ANKS1A
ANKS1B
ANP32E
ANTXR1
AP2A1
AP2A2
AP2B1
AP2M1
AP2S1
AREL1
ARIH1
ARIH2
ARMC1
ARRB2
ASB11
ASB2
ASCC2
ASCC3
ASXL1
ASXL2
ATP5PD
ATXN3
ATXN3L
ATXN7L3
AUP1
BABAM1
BABAM2
BAP1
BARD1
BARX1
BCAS2
BCR
BECN1
BFAR
BIN1
BIRC2
BIRC3
BRAP
BRCA1
BRCC3
BRF1
BSG
BTD
BTRC
C8orf34
CAPN15
CASP8
CAVIN1
CAVIN3
CBL
CBLB
CBLC
CBR1
CBR3
CCDC50
CCDC92
CD2
CD2AP
CDC20
CDC42
CDC45
CDH2
CDH22
CDIP1
CDK17
CDY1B
CENPE
CEP164
CEP192
CEP55
CEP83
CFAP36
CHD3
CHGA
CHP1
CHUK
CLN8
CLU
COL1A1
COPB1
CPT1A
CRACD
CTBP2
CTRC
CUEDC1
CUEDC2
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CYLD
DAXX
DAZAP2
DCUN1D1
DDI1
DDI2
DDX19B
DDX58
DECR2
DENR
DESI1
DHX15
DLGAP4
DMBX1
DNAH7
DNAJB2
DNASE2B
DOCK6
DPH1
DPY30
ECE2
EFS
EIF3A
ELL
ELOVL5
EP300
EPN1
EPN2
EPN3
EPS15
EPS15L1
ERCC6
ERGIC2
ERVK13-1
EXOSC8
FAAP20
FAF1
FAM168A
FAN1
FAT1
FBH1
FBXL15
FBXO44
FCHO2
FETUB
FGA
FIS1
FLOT1
FLOT2
FSHR
GARNL3
GBF1
GFPT2
GFUS
GGA1
GGA3
GLG1
GRB2
GTF2H1
GTF2I
GTF2IRD1
H2AC18
H2AC20
H2BC21
HACD1
HACD2
HDAC5
HDAC6
HECW1
HERC1
HERC2
HERC3
HERC4
HGS
HLTF
HMGN2
HNRNPM
HPDL
HRNR
HSD17B11
HSPA8
HSPG2
HUWE1
HYDIN
HYDIN2
IDE
IGF1R
IKBKB
IKBKG
ILF3
ING1
INPPL1
IRS1
ISX
ITCH
ITGAV
ITSN2
JOSD1
JOSD2
JUN
KCTD7
KDM3B
KEAP1
KEL
KHDRBS1
KIAA0586
KLHL11
KLHL13
KLHL7
LACTB
LAMA1
LAMA5
LAMB1
LAMC1
LAPTM5
LARP1B
LIMA1
LINC02593
LNPK
LTF
LTN1
MACF1
MAD1L1
MALT1
MAP2K4
MAP3K7
MAP4
MAPRE2
MARCHF6
MARCHF7
MBOAT7
MDM2
MDM4
MDN1
MED15
MINDY1
MINDY2
MINDY3
MINDY4
MORC3
MRPL37
MTERF4
MTURN
MUC16
MUC5B
MUL1
MVP
MYCBP
MYL1
MYL3
MYO6
NAA10
NAT10
NBPF1
NBPF10
NBPF11
NBPF12
NBPF14
NBPF8
NBPF9
NBR1
NCK2
NCKAP5L
NCOA6
NDC1
NDUFB9
NDUFS8
NEDD4
NEDD4L
NEK8
NEURL3
NFIA
NFX1
NPLOC4
NPM1
NPTN
NSFL1C
NSMCE1
NT5C1B
NXPH4
OGT
OPA3
OPRM1
OPTN
OR7G3
OSBPL8
OTOG
OTUB1
OTUB2
OTUD1
OTUD3
OTUD4
OTUD5
OTUD6A
OTUD6B
OTUD7A
OTUD7B
P4HTM
PABPC4
PARP10
PCBP2
PCMTD1
PDCD6IP
PDE12
PDS5A
PEDS1
PELI1
PHF20L1
PHPT1
PIK3C2B
PLAA
PLEC
PLEKHB2
PLSCR4
PMS2
POLH
POLI
POLR2C
POP5
PPA1
PPARG
PPARGC1A
PPL
PPM1D
PRAME
PRDX4
PRKCI
PRKN
PRPF8
PRR23B
PSMA6
PSMC1
PSMC2
PSMC3
PSMC4
PSMC5
PSMC6
PSMD1
PSMD10
PSMD11
PSMD12
PSMD13
PSMD2
PSMD3
PSMD4
PSMD5
PSMD6
PSMD7
PSMD8
PTH1R
PTOV1
PTPN2
PTPN23
PUS7L
R3HDM4
RABEP1
RABEP2
RABGEF1
RAC1
RAD18
RAD23A
RAD23B
RAG1
RASAL2
RB1CC1
RBCK1
RC3H2
RCHY1
RECQL
REV1
RFC1
RGPD3
RGS2
RIOK3
RNF11
RNF111
RNF114
RNF115
RNF123
RNF125
RNF126
RNF130
RNF144A
RNF144B
RNF145
RNF151
RNF165
RNF168
RNF169
RNF181
RNF182
RNF2
RNF216
RNF31
RNF38
RNF4
RNF5
RNF8
RPL12
RPL7L1
RPN1
RPS3
RTL8B
RTL8C
RTTN
RYBP
SBF2
SCD
SDC4
SDCBP
SDF2
SDK1
SEMA3F
SEPTIN1
SEPTIN7P2
SFPQ
SGK1
SGPP1
SH3KBP1
SHARPIN
SLC27A2
SLC38A5
SLC5A6
SLIT2
SLX4
SMAD1
SMURF1
SMURF2
SMYD4
SNCA
SNRNP25
SNRPA
SNTB2
SNTG1
SOCS5
SPAG1
SPECC1L
SPRTN
SQSTM1
SRPRB
STAM
STAM2
STAMBP
STUB1
SUN5
SYNE2
TAB1
TAB2
TAC3
TAPBP
TAX1BP1
TBC1D15
TBC1D5
TBXAS1
TCAF1
TCEAL1
TCHH
TCOF1
TCP10L3
TDRD3
THG1L
TIAM1
TMEM120A
TMEM132A
TMEM160
TMEM201
TMEM223
TNFAIP3
TNFAIP6
TNIP1
TNIP2
TNIP3
TNRC6A
TNRC6C
TOLLIP
TOM1
TOM1L1
TOM1L2
TOPORS
TOR1AIP2
TRAF2
TRAF3IP2
TRAF5
TRAF6
TRAFD1
TRAM1
TRIM17
TRIM21
TRIM23
TRIM25
TRIM32
TRIM36
TRIM39
TRIM5
TRIP12
TRIP4
TSG101
TTC28
TTC36
TTF2
TUBA3C
TUBA3D
TUBGCP2
UBA1
UBA2
UBA6
UBAC1
UBAC2
UBAP1
UBASH3A
UBASH3B
UBE2D1
UBE2D2
UBE2D4
UBE2E3
UBE2G2
UBE2J1
UBE2J2
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2V1
UBE2V2
UBE3A
UBFD1
UBL7
UBQLN1
UBQLN2
UBQLN4
UBR4
UBR5
UBXN1
UBXN6
UBXN7
UCHL1
UCHL5
UEVLD
UFD1
UIMC1
ULK1
UNC79
UNC93B3
USP1
USP10
USP11
USP12
USP13
USP14
USP16
USP19
USP21
USP22
USP24
USP25
USP27X
USP28
USP3
USP30
USP31
USP32
USP33
USP34
USP35
USP36
USP37
USP38
USP4
USP40
USP42
USP45
USP46
USP47
USP48
USP5
USP53
USP54
USP6
USP7
USP8
USP9X
USP9Y
VCP
VCPIP1
VPS28
VPS36
VPS37A
VPS37C
VPS50
WARS1
WBP2
WDR33
WDR48
WFDC8
WRNIP1
WWP1
WWP2
XIAP
XPNPEP1
XRCC5
XRCC6
YAF2
YARS2
YIPF5
YOD1
YWHAB
YWHAG
YWHAZ
ZBTB1
ZC3H12A
ZCWPW2
ZFAND2B
ZFAND3
ZFAND5
ZFAND6
ZFYVE9
ZHX1
ZNF148
ZNF213
ZNF451
ZNF705G
ZNF716
ZNF792
ZNRF1
ZNRF2
ZRANB1
ZUP1
7 interacting genes:
ARRDC3
RIPK1
RNF8
RPS3A
SH3GL1
TNFAIP3
UBC
Entrez ID
7316
152137
HPRD ID
07038
06463
Ensembl ID
ENSG00000150991
ENSG00000152492
Uniprot IDs
P0CG48
Q8IVM0
PDB IDs
1C3T
1CMX
1D3Z
1F9J
1FXT
1G6J
1GJZ
1NBF
1OGW
1Q5W
1S1Q
1SIF
1TBE
1UBI
1UBQ
1UD7
1XD3
1XQQ
1YX5
1YX6
1ZGU
1ZO6
2AYO
2BGF
2DEN
2FUH
2G45
2GBJ
2GBK
2GBM
2GBN
2GBR
2GMI
2HTH
2IBI
2J7Q
2JF5
2JRI
2JY6
2JZZ
2K25
2K6D
2K8B
2K8C
2KDF
2KHW
2KJH
2KLG
2KN5
2KX0
2L3Z
2LD9
2LVO
2LVP
2LVQ
2LZ6
2MBO
2MBQ
2MCN
2MI8
2MJ5
2MOR
2MRE
2MWS
2N2K
2NR2
2O6V
2OJR
2PE9
2PEA
2RR9
2RU6
2W9N
2WDT
2XEW
2Y5B
2Z59
2ZCB
2ZVN
2ZVO
3A33
3ALB
3AUL
3B08
3B0A
3BY4
3C0R
3DVG
3DVN
3EEC
3EFU
3EHV
3H7P
3H7S
3HM3
3I3T
3IFW
3IHP
3JSV
3JVZ
3JW0
3K9O
3K9P
3KVF
3KW5
3LDZ
3MHS
3MTN
3N30
3N32
3N3K
3NS8
3O65
3OFI
3OJ3
3OJ4
3ONS
3PRM
3PT2
3PTF
3Q3F
3RUL
3TMP
3U30
3UGB
3V6C
3V6E
3VFK
3VUW
3VUX
3VUY
3WXE
3WXF
3ZLZ
3ZNH
3ZNI
3ZNZ
4AP4
4AUQ
4BOS
4BOZ
4BVU
4DDG
4DDI
4DHJ
4DHZ
4FJV
4HK2
4HXD
4I6L
4I6N
4IG7
4IUM
4JQW
4K1R
4K7S
4K7U
4K7W
4KSK
4KSL
4LCD
4LDT
4MDK
4MM3
4MSM
4MSQ
4NQK
4UN2
4V3K
4V3L
4WZP
4XOK
4XOL
4ZQS
5A5B
5AF4
5AF5
5AF6
5AIT
5AIU
5B83
5C7J
5C7M
5E6J
5H07
5NL4
5NLF
5NLI
5NMC
5OE7
5OHV
5OXH
5OXI
5UDH
5WQ4
5ZQ3
5ZQ4
5ZQ5
5ZQ6
5ZQ7
6A43
6A44
6AQR
6B7M
6B7O
6EQI
6K2U
6KBE
6N13
6N6R
6NQA
6NXK
6OI4
6P5B
6Q00
6QML
6RYA
6S53
6SQR
6T7F
6T9L
6TNF
6TTU
6ULH
6UMP
6UMS
6UPU
6V5D
6VAE
6VAF
6VEN
6W9D
6W9R
6W9S
6WJD
7BXG
6LAN
Enriched GO Terms of Interacting Partners
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