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U2AF1 and PRPF19
Data Source:
BioGRID
(two hybrid)
U2AF1
PRPF19
Description
U2 small nuclear RNA auxiliary factor 1
pre-mRNA processing factor 19
Image
GO Annotations
Cellular Component
Nucleoplasm
Spliceosomal Complex
Cajal Body
Nuclear Speck
Catalytic Step 2 Spliceosome
U2AF Complex
Prp19 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Lipid Droplet
Spindle
Membrane
Nuclear Speck
Site Of Double-strand Break
U2-type Catalytic Step 1 Spliceosome
U2-type Catalytic Step 2 Spliceosome
Catalytic Step 2 Spliceosome
Molecular Function
RNA Binding
Protein Binding
Pre-mRNA 3'-splice Site Binding
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin-ubiquitin Ligase Activity
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
MRNA Splicing, Via Spliceosome
MRNA Processing
RNA Export From Nucleus
MRNA Export From Nucleus
RNA Splicing
MRNA 3'-end Processing
Protein Polyubiquitination
Spliceosomal Tri-snRNP Complex Assembly
Spliceosomal Complex Assembly
Generation Of Catalytic Spliceosome For First Transesterification Step
MRNA Splicing, Via Spliceosome
Inner Cell Mass Cell Proliferation
Transcription-coupled Nucleotide-excision Repair
Double-strand Break Repair Via Nonhomologous End Joining
Lipid Biosynthetic Process
Proteasomal Protein Catabolic Process
Cellular Protein Localization
Positive Regulation Of Neuron Differentiation
Positive Regulation Of MRNA Splicing, Via Spliceosome
Positive Regulation Of Astrocyte Differentiation
Protein K63-linked Ubiquitination
Signal Transduction Involved In DNA Damage Checkpoint
Pathways
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS
Blood and toenail selenium levels (
25343990
)
Interacting Genes
51 interacting genes:
AP1B1
AP2B1
CARNMT1
CHERP
CIR1
CLK2
DHX38
EFHC2
EPB41
FRA10AC1
HINFP
HNRNPK
HNRNPM
IL7R
JMJD6
KRT1
KRT75
MAP1B
MEOX2
MFAP1
MLH1
NDN
NKAP
NXF1
PABPC1
PRPF19
PRPF38A
PRPF4
PRPF40A
PTEN
RBM10
RNPS1
RP9
SF3A3
SF3B2
SNRNP35
SNRPD1
SRPK1
SRRM4
SRSF1
SRSF2
SRSF3
SUV39H1
TOE1
TRA2B
U2AF2
VEGFA
ZCCHC10
ZNF417
ZRANB2
ZRSR2
14 interacting genes:
DDX42
DNTT
EGLN3
ESR1
EXOC7
GSTK1
HSPB1
POLR2A
PRPF8
PSMB4
PTEN
RPA3
U2AF1
UBE2D3
Entrez ID
7307
27339
HPRD ID
01871
12214
Ensembl ID
ENSG00000160201
ENSG00000110107
Uniprot IDs
P0DN76
Q01081
Q7Z780
Q9UMS4
PDB IDs
1JMT
4LG8
5MQF
5XJC
5YZG
5Z56
5Z57
6FF7
6ICZ
6ID0
6ID1
6QDV
7A5P
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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