TNFRSF4 and DHX38

Data Source:
BioGRID (proximity labelling technology)

		TNFRSF4	DHX38
Description		TNF receptor superfamily member 4	DEAH-box helicase 38
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding
	Biological Process	Positive Regulation Of Immunoglobulin Production Inflammatory Response Immune Response Positive Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways		TNFs bind their physiological receptors	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Blood protein levels ( 28240269 23696881) Cholesterol, total ( 25961943 20686565) Coronary artery disease ( 29212778) Depression ( 29700475) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol ( 25961943 20686565) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 22916037) Red blood cell count ( 32888494) Serum metabolite levels (CMS) ( 31636271) Urate levels ( 31578528)
Interacting Genes		10 interacting genes: NUFIP2 RC3H1 SIVA1 TNFRSF9 TNFSF4 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5	8 interacting genes: CDC40 CSNK2A1 MFAP1 PPP4C SNRNP200 TERF2IP U2AF1 WBP4
Entrez ID		7293	9785
HPRD ID		02636	05720
Ensembl ID		ENSG00000186827	ENSG00000140829
Uniprot IDs		P43489	Q92620
PDB IDs		1D0A 2HEV 2HEY 6OGX 6OKM 6OKN	5YZG 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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