C5AR1 and ARRB1

Data Source:
HPRD (in vivo)

		C5AR1	ARRB1
Description		complement C5a receptor 1	arrestin beta 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Secretory Granule Membrane Apical Part Of Cell	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Lysosomal Membrane Endosome Cytosol Plasma Membrane Clathrin-coated Pit Postsynaptic Density Basolateral Plasma Membrane Nuclear Body Cytoplasmic Vesicle Membrane Pseudopodium Cytoplasmic Vesicle Dendritic Spine Postsynaptic Membrane
	Molecular Function	Complement Component C5a Binding Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity	G Protein-coupled Receptor Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Enzyme Inhibitor Activity GTPase Activator Activity Insulin-like Growth Factor Receptor Binding Protein Binding Transcription Factor Binding Estrogen Receptor Binding Ubiquitin Protein Ligase Binding Alpha-1A Adrenergic Receptor Binding Alpha-1B Adrenergic Receptor Binding Angiotensin Receptor Binding Follicle-stimulating Hormone Receptor Binding V2 Vasopressin Receptor Binding AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Ion Channel Binding Protein Phosphorylated Amino Acid Binding Arrestin Family Protein Binding
	Biological Process	Activation Of MAPK Activity Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Proliferation In Hindbrain Regulation Of Complement Activation Neutrophil Chemotaxis Animal Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization Regulation Of Tau-protein Kinase Activity	Activation Of MAPK Activity Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation G Protein-coupled Receptor Internalization Positive Regulation Of Receptor Internalization Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Protein Transport Protein Ubiquitination Histone Acetylation Platelet Activation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of GTPase Activity Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of Histone Acetylation Response To Drug Follicle-stimulating Hormone Signaling Pathway Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Membrane Organization Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Histone H4 Acetylation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade	Activated NOTCH1 Transmits Signal to the Nucleus G alpha (s) signalling events Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Thrombin signalling through proteinase activated receptors (PARs) Activation of SMO Activation of SMO MAP2K and MAPK activation Ub-specific processing proteases Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Chronic periodontitis ( 25008200)	Obstructive sleep apnea trait (average respiratory event duration) ( 26977737) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS	56 interacting genes: ADH6 ADRB1 ADRB2 AGTR1 AP2B1 ARF6 BAG1 BTK C5AR1 CCR5 CDC42 CLTC CSK CXCR2 CYTH2 DVL1 DVL2 FGR FLNA GNB1 GNMT GPR50 GRK2 GSK3B HCK HCRTR1 JUN LIMK1 MAP2K3 MAP2K4 MAP3K5 MAPK1 MAPK10 MAPK3 MAPK9 MDM2 NEK6 NFKBIA NSF OPRD1 PDE4D PIK3R2 POT1 POU2F1 PRDM16 PRKN PTH1R PTHLH RALGDS RPL15 SASH1 SLC9A5 SREBF2 STAM TRHR ZBTB43
Entrez ID		728	408
HPRD ID		00224	00146
Ensembl ID		ENSG00000197405	ENSG00000137486
Uniprot IDs		P21730	B7Z1Q3 P49407
PDB IDs		5O9H 6C1Q 6C1R	2IV8 6PWC 6TKO 6UP7
Enriched GO Terms of Interacting Partners?
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