TRPC6 and RNF24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TRPC6	RNF24
Description		transient receptor potential cation channel subfamily C member 6	ring finger protein 24
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Cation Channel Complex Slit Diaphragm	Golgi Membrane Golgi Apparatus Endomembrane System Integral Component Of Membrane
	Molecular Function	Actin Binding Cation Channel Activity Protein Binding Store-operated Calcium Channel Activity Clathrin Binding Protein Homodimerization Activity Actinin Binding ATPase Binding Inositol 1,4,5 Trisphosphate Binding	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cation Transport Manganese Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Single Fertilization Aging Positive Regulation Of Peptidyl-threonine Phosphorylation Platelet Activation Neuron Differentiation Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Neuron Differentiation Negative Regulation Of Dendrite Morphogenesis Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Hypoxia	Protein Ubiquitination
Pathways		Effects of PIP2 hydrolysis Elevation of cytosolic Ca2+ levels TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Change in LVEF in response to paclitaxel and trastuzumab in HER2+ breast cancer ( 28763429) General risk tolerance (MTAG) ( 30643258) Lung adenocarcinoma ( 28604730) Menarche (age at onset) ( 25231870) Plateletcrit ( 32888494) Severity of nausea and vomiting of pregnancy ( 29563502) White blood cell count ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Nevirapine-induced hypersensitivity in HIV (drug-induced liver injury) ( 28062682) PR interval ( 32439900) Response to antidepressants in depression ( 27622933)
Interacting Genes		9 interacting genes: FYN ITPR3 MX1 ORAI1 RNF24 SRC TRPC3 TRPC7 TRPM2	17 interacting genes: ABHD5 ARMC1 BNIP3 CNIH1 GOLT1A LHFPL3 MFSD14B NKG7 NRSN1 NT5E PLP1 SLC10A6 TIMMDC1 TMX2 TRPC6 UQCRH VAMP1
Entrez ID		7225	11237
HPRD ID		04710	10198
Ensembl ID		ENSG00000137672	ENSG00000101236
Uniprot IDs		Q9Y210	Q9Y225
PDB IDs		5YX9 6UZ8 6UZA 7A6U	2EP4
Enriched GO Terms of Interacting Partners?
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