TRIO and DAP

Data Source:
BioGRID (proximity labelling technology)

		TRIO	DAP
Description		trio Rho guanine nucleotide exchange factor	death associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell Projection
	Molecular Function	Protein Serine/threonine Kinase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Death Domain Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Central Nervous System Development Positive Regulation Of Apoptotic Process Negative Regulation Of Fat Cell Differentiation Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Autophagy Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Autophagy Negative Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Amino Acid Starvation Negative Regulation Of Transcription, DNA-templated Apoptotic Signaling Pathway
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling
Drugs
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel) ( 24025145) Antidepressant treatment resistance (number of drugs prescribed) ( 30700811) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Electroencephalogram traits ( 25387704) High density lipoprotein cholesterol levels ( 30498476) Intake of total sugars ( 31005972) Major depressive disorder ( 27777418) Paclitaxel-induced neuropathy ( 23776197) Physiological dysregulation (Mahalanobis distance) ( 32235003) Waist circumference ( 28552196)	Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Gut microbiota (functional units) ( 27694959) Height ( 28270201) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483) Metabolite levels (Pyroglutamine) ( 23934736) Pulse pressure ( 27841878) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ulcerative colitis ( 21297633)
Interacting Genes		13 interacting genes: BLMH CDC42 CDC5L DISC1 EXOC1 FLNA ITSN2 LIMS1 MAPRE1 PTK2 PTPRF RAC1 RHOA	1 interacting genes: SETDB1
Entrez ID		7204	1611
HPRD ID		03537	02977
Ensembl ID		ENSG00000038382	ENSG00000112977
Uniprot IDs		O75962	B4DQ75 P51397
PDB IDs		1NTY 2NZ8 6D8Z
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?