TRHR and TRH

Data Source:
HPRD (in vivo, in vitro)

		TRHR	TRH
Description		thyrotropin releasing hormone receptor	thyrotropin releasing hormone
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Nucleus Plasma Membrane Secretory Granule
	Molecular Function	Thyrotropin-releasing Hormone Receptor Activity Protein Binding	Protein Binding Thyrotropin-releasing Hormone Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway	Response To Hypoxia Histamine Metabolic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Cold Response To Glucose Hormone-mediated Signaling Pathway Negative Regulation Of Glutamate Secretion Positive Regulation Of Gamma-aminobutyric Acid Secretion Positive Regulation Of Insulin Secretion Eating Behavior Response To Ethanol Response To Corticosterone Negative Regulation Of Feeding Behavior
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Protirelin
Diseases
GWAS		Body mass (lean) ( 19268274) Daytime sleep phenotypes ( 27126917) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Pulse pressure ( 30224653) Type 2 diabetes ( 30297969)	Alzheimer's disease ( 30636644) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ARRB1 C1QL4 COMT EFNA5 FAM241B FXYD6-FXYD2 GJB2 IER3IP1 NIPAL4 PEDS1-UBE2V1 SLC39A2 SLC39A9 SLC41A1 TMEFF2 TMEM218 TMEM239 TRH UBE2J1 YIPF6	5 interacting genes: ARRB2 CPE KCNIP4 LCN2 TRHR
Entrez ID		7201	7200
HPRD ID		11767	08944
Ensembl ID		ENSG00000174417	ENSG00000170893
Uniprot IDs		P34981	P20396
PDB IDs
Enriched GO Terms of Interacting Partners?
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