C2 and C5

Data Source:
HPRD (in vitro)

		C2	C5
Description		complement C2	complement C5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Metal Ion Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Proteolysis Complement Activation Complement Activation, Classical Pathway Response To Nutrient Regulation Of Complement Activation Innate Immune Response Positive Regulation Of Apoptotic Cell Clearance	Activation Of MAPK Activity In Utero Embryonic Development Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Positive Regulation Of Chemokine Production Positive Regulation Of Angiogenesis Cell Chemotaxis
Pathways		Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade	Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs			Human immunoglobulin G Eculizumab Zinc Copper Ravulizumab Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus	Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Circulating myeloperoxidase levels (serum) ( 23620142) Coffee consumption ( 31046077) Coronary artery disease ( 29212778 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Endometriosis ( 28881265) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in diabetes ( 31451708) Hepatocellular carcinoma ( 21105107) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Platelet aggregation ( 29185836) Prostate cancer ( 23535732) Sulfasalazine-induced agranulocytosis ( 28762467) Systemic lupus erythematosus ( 24871463) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		14 interacting genes: C3 C4B C5 CREB3 EBP ERGIC3 FAM209A MASP1 MUC1 PSMA4 SEC11C SLC10A1 SLC35C2 STOM	22 interacting genes: ANKS6 AQP6 C2 C3 C5AR1 C6 C7 C8B CPB2 CPLX4 CPN1 CREB3L1 EBP KEL KIR3DL3 LMNA MMGT1 NEMP1 PGRMC2 POU6F2 SSMEM1 VEZT
Entrez ID		717	727
HPRD ID		08939	00405
Ensembl ID		ENSG00000166278	ENSG00000106804
Uniprot IDs		A0A0G2JL69 B4DQI1 B4DV48 P06681 Q53HP3 Q5JP69 Q8N6L6	P01031 Q59GS8
PDB IDs		2I6Q 2I6S 2ODP 2ODQ 3ERB	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04 6RPT
Enriched GO Terms of Interacting Partners?
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