Wiki-Pi
About
Search
Browse
People
Updates
Search
TOP2A and FBXO28
Data Source:
BioGRID
(pull down)
TOP2A
FBXO28
Description
DNA topoisomerase II alpha
F-box protein 28
Image
No pdb structure
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Centromeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centriole
DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Complex
Protein-containing Complex
Ribonucleoprotein Complex
Kinetochore
Condensed Chromosome Kinetochore
Molecular Function
Magnesium Ion Binding
DNA Binding
Chromatin Binding
RNA Binding
DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
DNA Binding, Bending
Enzyme Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Ubiquitin Binding
Protein Heterodimerization Activity
Protein Binding
Identical Protein Binding
Biological Process
Resolution Of Meiotic Recombination Intermediates
Sister Chromatid Segregation
Hematopoietic Progenitor Cell Differentiation
DNA Topological Change
DNA Ligation
Cellular Response To DNA Damage Stimulus
Chromosome Segregation
Female Meiotic Nuclear Division
Apoptotic Chromosome Condensation
Embryonic Cleavage
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Negative Regulation Of DNA Duplex Unwinding
Protein Polyubiquitination
Pathways
Transcription of E2F targets under negative control by DREAM complex
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Drugs
Moxifloxacin
Amsacrine
Dexrazoxane
Valrubicin
Teniposide
Epirubicin
Enoxacin
Pefloxacin
Ciprofloxacin
Trovafloxacin
Daunorubicin
Etoposide
Dactinomycin
Lomefloxacin
Doxorubicin
Norfloxacin
Ofloxacin
Idarubicin
Podofilox
Mitoxantrone
Sparfloxacin
Genistein
Fleroxacin
Lucanthone
Banoxantrone
SP1049C
Amonafide
Elsamitrucin
13-deoxydoxorubicin
RTA 744
Aldoxorubicin
ZEN-012
Amrubicin
Becatecarin
Annamycin
Declopramide
Finafloxacin
Diseases
GWAS
Hip circumference (
25673412
)
Hip circumference adjusted for BMI (
25673412
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
29 interacting genes:
BRCA1
CDK1
COPS5
CSNK2A1
DFFB
DHX9
FBXO28
HDAC1
HDAC2
JUN
MAPK1
PIAS4
PIN1
PLK1
PRKCA
PRKCB
PRKCG
RB1
RNF168
SMURF2
SRPK1
SUMO1
SUMO2
SUMO4
TOP2B
TP53
UBE2I
XPO1
YWHAE
22 interacting genes:
AGGF1
CAVIN1
CSNK2A1
CTNNA3
EMILIN1
EMILIN3
EXOC7
GCC1
GK
GOLGA2
GOLGA6L9
HOMER3
PLEKHF2
PMF1
PSMC3
SDCBP2
SKP1
SPAG5
STX1B
TOP2A
TRAF2
TRAF5
Entrez ID
7153
23219
HPRD ID
00536
12367
Ensembl ID
ENSG00000131747
ENSG00000143756
Uniprot IDs
P11388
Q9NVF7
PDB IDs
1LWZ
1ZXM
1ZXN
4FM9
4R1F
5GWK
5NNE
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?