TNXB and CEACAM6

Data Source:
BioGRID (two hybrid)

		TNXB	CEACAM6
Description		tenascin XB	CEA cell adhesion molecule 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Anchored Component Of Membrane Azurophil Granule Membrane
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Heparin Binding Collagen Fibril Binding	Protein Binding Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Cell Adhesion Actin Cytoskeleton Organization Collagen Fibril Organization Collagen Metabolic Process Elastic Fiber Assembly	Apoptotic Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Negative Regulation Of Anoikis
Pathways		ECM proteoglycans	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases		Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
GWAS		Age-related macular degeneration ( 22694956) Alzheimer's disease ( 30636644) Asthma ( 31619474) Atopic dermatitis ( 23886662) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 32469254) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil counts ( 27863252) Hemoglobin levels ( 32327693) HIV-1 control ( 20041166) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 30054594) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean corpuscular volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Neutrophil count ( 32888494) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Platelet distribution width ( 32888494) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Schizophrenia ( 30285260) Shingles ( 28928442) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26316170 26502338 21408207 28714469) Systolic blood pressure ( 28739976) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)	Serum carcinoembryonic antigen levels ( 31666285)
Interacting Genes		6 interacting genes: BANP CEACAM6 POU6F2 TGM7 VEGFA VEGFB	32 interacting genes: APP ASPG CARTPT CEACAM1 CEACAM5 CEACAM7 CEACAM8 CIB1 CSTF2 EXOC3L1 FOXH1 GCM2 GPANK1 HGS HPCAL4 KANK2 MSS51 MYOZ1 PITX1 POM121 QRICH1 RHOXF2 SHC3 SMARCD1 TLX3 TNXB UBQLN2 VENTX VEZF1 WWOX ZMYND19 ZNF76
Entrez ID		7148	4680
HPRD ID		02993	01233
Ensembl ID		ENSG00000168477	ENSG00000086548
Uniprot IDs		O95680 O95681 P22105 Q6IPK3 Q9Y464	P40199
PDB IDs		2CUH 2CUI 2CUM	4WHC 4WTZ 4Y8A 4YIQ
Enriched GO Terms of Interacting Partners?
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