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TNFRSF1A and PRKCD
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
TNFRSF1A
PRKCD
Description
TNF receptor superfamily member 1A
protein kinase C delta
Image
GO Annotations
Cellular Component
Golgi Membrane
Tumor Necrosis Factor Receptor Superfamily Complex
Extracellular Region
Extracellular Space
Mitochondrion
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Membrane
Receptor Complex
Membrane Raft
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Tumor Necrosis Factor Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Aortic Valve Development
Pulmonary Valve Development
Negative Regulation Of Extracellular Matrix Constituent Secretion
Prostaglandin Metabolic Process
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Negative Regulation Of Cardiac Muscle Hypertrophy
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Positive Regulation Of Inflammatory Response
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Protein Localization To Plasma Membrane
Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Regulation Of Establishment Of Endothelial Barrier
Positive Regulation Of Ceramide Biosynthetic Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFs bind their physiological receptors
Interleukin-10 signaling
TNF signaling
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Drugs
6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2',3':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Tasonermin
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Diseases
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS); Familial periodic fever
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) (
23648065
)
Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) (
23648065
)
Alopecia areata (
25608926
)
Ankylosing spondylitis (
23749187
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Colorectal cancer (
24836286
)
Crohn's disease (
26192919
)
Eosinophil counts (
32888494
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
)
Monocyte count (
32888494
27863252
)
Multiple sclerosis (
31604244
24076602
19525953
21833088
27386562
)
Neutrophil percentage of white cells (
32888494
)
Platelet count (
32888494
27863252
)
Plateletcrit (
32888494
27863252
)
Primary biliary cholangitis (
28425483
21399635
26394269
)
Primary biliary cirrhosis (
22961000
)
White blood cell count (
32888494
)
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
67 interacting genes:
ADAM17
AKT1
ATF6
BAG4
BCL10
CASP10
CASP7
CCND2
CDK6
CDKN2B
CHUK
CLIP3
CSNK1A1L
DAPK1
DAXX
EGFR
ERAP1
ERN1
FANCD2
GRB2
GYS2
HRG
HSP90AA1
HSPA8
IKBKB
IKBKG
JAK1
JAK2
LTA
LTB
MADD
MAGEH1
MAPK1
MOAP1
MYOC
NSMAF
PIP4K2B
PRDX3
PRKCD
PSMD2
PTK2
PTPN11
PTPN6
RACK1
RASSF1
RIPK1
RIPK2
RIPK3
SGTA
SRC
STAMBP
STAT1
STK11
SUMO1
SYK
TNF
TNFRSF25
TNFSF13
TRADD
TRAF1
TRAF2
TRAF3
TRAP1
TRPC4AP
UBE2I
UBQLN1
UCHL1
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
Entrez ID
7132
5580
HPRD ID
01861
01501
Ensembl ID
ENSG00000067182
ENSG00000163932
Uniprot IDs
J9PH39
P19438
A0A024R328
B4DFV1
Q05655
PDB IDs
1EXT
1FT4
1ICH
1NCF
1TNR
7K7A
1YRK
2YUU
Enriched GO Terms of Interacting Partners
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