Wiki-Pi
About
Search
Browse
People
Updates
Search
TNF and STX1A
Data Source:
BioGRID
(two hybrid)
TNF
STX1A
Description
tumor necrosis factor
syntaxin 1A
Image
No pdb structure
GO Annotations
Cellular Component
Phagocytic Cup
Extracellular Region
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane Raft
Recycling Endosome
Extracellular Region
Cytosol
Plasma Membrane
Synaptic Vesicle
Voltage-gated Potassium Channel Complex
Endomembrane System
Postsynaptic Density
Integral Component Of Membrane
Secretory Granule
Integral Component Of Synaptic Vesicle Membrane
Axon
SNARE Complex
Nuclear Membrane
Actomyosin
Neuron Projection
Presynaptic Active Zone Membrane
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Glutamatergic Synapse
Integral Component Of Presynaptic Membrane
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
Protease Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Identical Protein Binding
SNARE Binding
SNAP Receptor Activity
Protein Binding
Calcium Channel Inhibitor Activity
Chloride Channel Inhibitor Activity
Kinase Binding
Protein Domain Specific Binding
Myosin Head/neck Binding
Identical Protein Binding
ATP-dependent Protein Binding
Ion Channel Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Calcium-dependent Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Activation Of MAPKKK Activity
Activation Of MAPK Activity
Microglial Cell Activation
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Phosphorylation
Negative Regulation Of Endothelial Cell Proliferation
Chronic Inflammatory Response To Antigenic Stimulus
Regulation Of Immunoglobulin Production
Negative Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Glucose Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Humoral Immune Response
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Virus
Response To Salt Stress
Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Alkaline Phosphatase Activity
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Lipid Storage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Cytokine-mediated Signaling Pathway
Extracellular Matrix Organization
Osteoclast Differentiation
Sequestering Of Triglyceride
Cortical Actin Cytoskeleton Organization
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Fever Generation
Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Interleukin-6 Production
Positive Regulation Of Chemokine Production
Positive Regulation Of Fractalkine Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Peptidyl-serine Phosphorylation
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Heterotypic Cell-cell Adhesion
Negative Regulation Of Myosin-light-chain-phosphatase Activity
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Protein-containing Complex Disassembly
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Protein Kinase B Signaling
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Nitric Oxide Biosynthetic Process
Regulation Of Fat Cell Differentiation
Negative Regulation Of Fat Cell Differentiation
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Osteoclast Differentiation
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Cell Adhesion
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Translational Initiation By Iron
Negative Regulation Of Glucose Import
Positive Regulation Of JNK Cascade
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Astrocyte Activation
Embryonic Digestive Tract Development
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Inflammatory Response
Positive Regulation Of Phagocytosis
Negative Regulation Of Neurogenesis
Regulation Of Insulin Secretion
Positive Regulation Of Synaptic Transmission
Regulation Of Synapse Organization
Defense Response To Gram-positive Bacterium
Cognition
Leukocyte Tethering Or Rolling
Negative Regulation Of Lipid Catabolic Process
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Membrane Protein Ectodomain Proteolysis
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Protein Transport
Response To Glucocorticoid
Positive Regulation Of Hair Follicle Development
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Synaptic Transmission, Glutamatergic
Positive Regulation Of Glial Cell Proliferation
Positive Regulation Of Vitamin D Biosynthetic Process
Positive Regulation Of Calcidiol 1-monooxygenase Activity
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Regulation Of Branching Involved In Salivary Gland Morphogenesis
Negative Regulation Of Vascular Wound Healing
Negative Regulation Of Branching Involved In Lung Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Cellular Response To Amino Acid Stimulus
Cellular Response To Nicotine
Cellular Response To Organic Cyclic Compound
Death-inducing Signaling Complex Assembly
Positive Regulation Of Mononuclear Cell Migration
Positive Regulation Of Podosome Assembly
Endothelial Cell Apoptotic Process
Protein Localization To Plasma Membrane
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Positive Regulation Of Neuroinflammatory Response
Positive Regulation Of Interleukin-33 Production
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Amyloid-beta Clearance
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Synoviocyte Proliferation
Positive Regulation Of Superoxide Dismutase Activity
Positive Regulation Of Amyloid-beta Formation
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Plasma Membrane
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of I-kappaB Phosphorylation
Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Positive Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Blood Microparticle Formation
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Neurotransmitter Secretion
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Neurotransmitter Secretion
Response To Gravity
Positive Regulation Of Norepinephrine Secretion
Regulation Of Synaptic Vesicle Priming
Glutamate Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Docking
Protein Sumoylation
Calcium-ion Regulated Exocytosis
Cytokine-mediated Signaling Pathway
Insulin Secretion
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Secretion By Cell
Positive Regulation Of Catecholamine Secretion
SNARE Complex Assembly
Positive Regulation Of Calcium Ion-dependent Exocytosis
Vesicle Docking
Synaptic Vesicle Endocytosis
Regulation Of Insulin Secretion
Protein Localization To Membrane
Positive Regulation Of Excitatory Postsynaptic Potential
Pathways
Transcriptional regulation of white adipocyte differentiation
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production
TNFR2 non-canonical NF-kB pathway
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
TNF signaling
Serotonin Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Insulin processing
Regulation of insulin secretion
Other interleukin signaling
Toxicity of botulinum toxin type C (botC)
LGI-ADAM interactions
Neurexins and neuroligins
GABA synthesis, release, reuptake and degradation
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Etanercept
Adalimumab
Infliximab
Chloroquine
Epinephrine
Pseudoephedrine
Thalidomide
Glucosamine
Clenbuterol
Pranlukast
Amrinone
Afelimomab
YSIL6
SD118
PN0621
OMS-103HP
Talmapimod
VX-702
Atiprimod
CRx-139
CYT007-TNFQb
Andrographolide
Ethyl pyruvate
AME-527
PR-104
Plinabulin
Dexanabinol
Onercept
Golimumab
Certolizumab pegol
Pomalidomide
Polaprezinc
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Bryostatin 1
Binimetinib
Dilmapimod
Glycyrrhizic acid
Diseases
Graft-versus-host disease
Asthma
Allograft rejection
Systemic lupus erythematosus
GWAS
AIDS progression (
19115949
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cervical cancer (
28806749
)
Crohn's disease (
21102463
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Neonatal lupus (
20662065
)
Psychosis (atypical) (
24132900
)
Pulse pressure (
30578418
)
Ulcerative colitis (
28067908
)
Malaria (
31844061
)
Triglyceride levels (
32203549
)
Interacting Genes
53 interacting genes:
ADAM17
ADAM9
AQP3
BCL2L13
BGN
BTNL9
C10orf67
CCDC107
CCDC70
CLDN7
CLEC10A
CREB3L1
CSF1
CYB5R3
DCN
FAM209A
FFAR2
FNDC9
FYN
IFNG
KASH5
LMNA
LRRC25
LRRTM2
LYN
MMP17
MRM3
NFKBIA
PAGE1
PANX1
PDIK1L
PIP4P2
PLEKHO1
POU2F1
PRTN3
RC3H1
RIPK1
RNF19B
SEC61A1
SGCB
SLC14A2
SLC30A4
SSMEM1
STOM
STX1A
TMPRSS2
TNFRSF1A
TNFRSF1B
TRAF2
VSIR
YWHAQ
ZCCHC12
ZFP36
167 interacting genes:
AARD
ABCC9
ABI3
AGTRAP
AIG1
ANKRD46
AOC3
APBA1
APOL2
APOL3
AQP3
ARL13B
ATP4B
ATP6V1B1
BET1
BLOC1S6
BNIP1
BTN2A2
C1GALT1
C4orf3
CACNA1D
CCSER2
CD81
CDC37
CDK5
CFTR
CLEC1A
CLN6
CMTM7
CPLX1
CSNK2A1
CSNK2A2
CXCL16
CYB5B
DAPK1
DDX49
EBAG9
EMD
ERG28
ETNK2
FAM3C
GIMAP1
GIMAP5
GOLM2
GOSR2
GPM6B
HMOX1
JAGN1
KCNB1
KIFC3
MAL
MALL
MIP
MMGT1
NAPA
NAPB
NINJ2
NKG7
NRM
NSF
PGAP2
PLN
PLP1
PLPP4
PLPP6
PNLIPRP1
PSMA3
RAB27A
RAB3IL1
RIMS1
RMDN2
RNF4
RTP2
SCNN1A
SCNN1B
SCNN1G
SDCBP
SEC22A
SEC22B
SEPTIN2
SEPTIN5
SERP1
SERP2
SLC6A1
SLC6A2
SLC6A3
SLC6A4
SLC6A5
SLC6A9
SMIM1
SMIM3
SNAP23
SNAP25
SNAP29
SNAP47
SNORC
SNPH
STRIT1
STX10
STX11
STX12
STX16
STX2
STX3
STX4
STX5
STX6
STX7
STX8
STXBP1
STXBP2
STXBP5
STXBP6
SUMO1P1
SYT1
SYT4
SYT7
SYTL4
TCEANC
TMEM100
TMEM120A
TMEM128
TMEM14C
TMEM199
TMEM222
TMEM254
TMEM41A
TMEM60
TNF
TRAF3IP3
TRDMT1
TSGA10IP
TSNARE1
TXLNA
TXLNB
UBE2I
UBTFL1
UNC13B
UPK1B
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP5
VAMP7
VAMP8
VAPB
VIM
VPS11
VPS16
VPS18
VSTM4
VTI1B
ZFPL1
ZNF12
ZNF136
ZNF250
ZNF440
ZNF441
ZNF479
ZNF490
ZNF557
ZNF696
ZNF707
ZNF785
ZNF835
Entrez ID
7124
6804
HPRD ID
01855
01721
Ensembl ID
ENSG00000232810
ENSG00000106089
Uniprot IDs
P01375
Q5STB3
Q16623
Q75ME0
PDB IDs
1A8M
1TNF
2AZ5
2E7A
2TUN
2ZJC
2ZPX
3ALQ
3IT8
3L9J
3WD5
4G3Y
4TSV
4TWT
4Y6O
5M2I
5M2J
5M2M
5MU8
5TSW
5UUI
5WUX
5YOY
6OOY
6OOZ
6OP0
6RMJ
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?