TFAM and COL8A2

Data Source:
BioGRID (two hybrid)

		TFAM	COL8A2
Description		transcription factor A, mitochondrial	collagen type VIII alpha 2 chain
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Protein-containing Complex Mitochondrial Nucleoid	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Mitochondrial Promoter Sequence-specific DNA Binding Transcription Coactivator Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding DNA Binding, Bending Heat Shock Protein Binding Mitochondrial Transcription Factor Activity Sequence-specific DNA Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity
	Biological Process	Mitochondrial Transcription Transcription Initiation From Mitochondrial Promoter Mitochondrion Organization Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Transcription, DNA-templated	Angiogenesis Extracellular Matrix Organization Camera-type Eye Morphogenesis Epithelial Cell Proliferation Cell-cell Adhesion
Pathways		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases			Posterior polymorphous corneal dystrophy (PPCD) Fuchs corneal dystrophy (FECD); Fuchs endothelial corneal dystrophy
GWAS		Blood urea nitrogen levels ( 29403010) Height ( 23456168) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs ( 28235828) Refractive error ( 32231278)	Central corneal thickness ( 32528159 29760442) Corneal structure ( 23291589) Early spontaneous preterm birth ( 31194736) Intraocular pressure ( 29617998 29785010 31959993)
Interacting Genes		10 interacting genes: AGTRAP ARL6IP1 COL8A2 MGST3 PNP STATH TECR TFB1M TFB2M TSPAN1	18 interacting genes: ARL13B ATP6V0E1 BSND COL8A1 CREB3L1 CYB5R3 DARS2 FAM209A FNDC9 GPR152 GPX8 LMNA MUC1 PEX12 PLEKHO1 SGTA TFAM TMX2
Entrez ID		7019	1296
HPRD ID		02702	08347
Ensembl ID		ENSG00000108064	ENSG00000171812
Uniprot IDs		E5KSU5 Q00059	E9PP49 P25067
PDB IDs		3FGH 3TMM 3TQ6 4NNU 4NOD 6ERP 6ERQ 6HB4 6HC3
Enriched GO Terms of Interacting Partners?
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