ACTC1 and DMTN

Data Source:
HPRD (in vivo)

		ACTC1	DMTN
Description		actin alpha cardiac muscle 1	dematin actin binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Actin Filament Focal Adhesion Membrane Sarcomere Lamellipodium Filopodium I Band Cell Body Extracellular Exosome Blood Microparticle	Cytosol Actin Filament Plasma Membrane Endomembrane System Postsynaptic Density Spectrin-associated Cytoskeleton Actin Cytoskeleton Cortical Cytoskeleton Platelet Dense Tubular Network Membrane Cell Projection Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	ATP Binding ATPase Activity Myosin Binding	Actin Binding Signaling Receptor Binding Protein Binding Spectrin Binding Protein Self-association Actin Filament Binding
	Biological Process	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Response To Drug Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration	Cytoskeleton Organization Regulation Of Cell Shape Regulation Of Lamellipodium Assembly Positive Regulation Of Fibroblast Migration Negative Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Cell-substrate Adhesion Lamellipodium Assembly Actin Cytoskeleton Organization Positive Regulation Of Blood Coagulation Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Peptidyl-serine Phosphorylation Calcium-mediated Signaling Using Intracellular Calcium Source Calcium-mediated Signaling Using Extracellular Calcium Source Erythrocyte Development Negative Regulation Of Peptidyl-tyrosine Phosphorylation Actin Filament Bundle Assembly Regulation Of Filopodium Assembly Actin Filament Capping Negative Regulation Of Focal Adhesion Assembly Transmembrane Transport Protein-containing Complex Assembly Protein Secretion By Platelet Cellular Response To Calcium Ion Cellular Response To CAMP Positive Regulation Of Wound Healing Negative Regulation Of Protein Targeting To Membrane Actin Filament Reorganization Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Platelet Aggregation Positive Regulation Of Integrin-mediated Signaling Pathway
Pathways		Striated Muscle Contraction	Miscellaneous transport and binding events
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Axial length ( 24144296) Refractive error ( 32231278 20835239)	Apolipoprotein B levels ( 32203549) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Total cholesterol levels ( 30275531)
Interacting Genes		41 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG ASH2L BCL11A C1QTNF9 CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1	16 interacting genes: ACTB ACTC1 APP CEP76 DYNC1LI2 EPB42 GOLGA2 NEDD4L PRKACA PROCR PTOV1 SNCA SNRPD2 SPTB TEX11 TRAF2
Entrez ID		70	2039
HPRD ID		00015	00506
Ensembl ID		ENSG00000159251	ENSG00000158856
Uniprot IDs		B3KPP5 P68032	Q08495
PDB IDs			1QZP 1ZV6
Enriched GO Terms of Interacting Partners?
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