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MLX and CASK
Data Source:
BioGRID
(two hybrid)
MLX
CASK
Description
MAX dimerization protein MLX
calcium/calmodulin dependent serine protein kinase
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Membrane
Basement Membrane
Nuclear Lamina
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Actin Cytoskeleton
Nuclear Matrix
Presynaptic Membrane
Ciliary Membrane
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Sequence-specific Double-stranded DNA Binding
Guanylate Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Cell-matrix Adhesion
Protein Phosphorylation
Cell Adhesion
Neurotransmitter Secretion
Negative Regulation Of Keratinocyte Proliferation
GMP Metabolic Process
GDP Metabolic Process
Negative Regulation Of Wound Healing
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways
ChREBP activates metabolic gene expression
ChREBP activates metabolic gene expression
Dopamine Neurotransmitter Release Cycle
Syndecan interactions
Nephrin family interactions
Neurexins and neuroligins
Neurexins and neuroligins
Assembly and cell surface presentation of NMDA receptors
Drugs
Formic acid
Fostamatinib
Diseases
FG syndrome (FGS); Opitz-Kaveggia syndrome
GWAS
Crohn's disease (
21102463
)
Type 2 diabetes (
30297969
29632382
30718926
)
Type 2 diabetes (time to event) (
32589924
)
Interacting Genes
31 interacting genes:
APP
BACH2
BEND7
CASK
CCT6A
DDIT4L
GABARAPL1
GABARAPL2
ID3
KRTAP13-3
LNX1
LNX2
MAD1L1
MEI4
MEOX1
MEOX2
MLXIP
MLXIPL
MNT
MXD1
MXD4
PIAS2
RBM39
RHBDD2
SAP30BP
TEPSIN
TLE5
TNNT2
UBE2I
ZBTB32
ZNF620
88 interacting genes:
AKAP9
APBA1
ATP2B4
BNIP3L
C20orf85
CADM1
CASKIN1
CDK9
CNTNAP2
CNTNAP4
DDX54
DLG1
DLG4
DNAJC5
DUSP3
ELL2
EPB41
EPS8
ERBIN
F11R
FCHSD2
FMR1
GCNT3
GLS2
GRIK2
GRIN2A
GTSE1
HGS
ID1
IL15RA
IL18
KCNA4
KCNJ12
KCNJ2
KCNJ4
KIF2A
KLC4
LIN7A
LIN7B
MAPRE1
MAPRE2
MARK2
MARS1
MED1
MLLT6
MLX
NDEL1
NPHS1
NRXN1
NRXN2
NRXN3
NTN4
P2RX7
PARD3B
PARD6G
PCBP2
PCM1
PKP2
PLK2
PPP4R3A
PRC1
PRKCI
PRKD2
PRKN
PRPF3
PTGS2
RAB3A
RBBP6
RBM10
RBM14
RBM5
RPA2
RPH3A
SDC1
SDC2
SDC3
SDC4
SF3B2
SH2D4A
SLAIN2
SRPK2
TANC1
TBR1
TRIM22
TSPYL2
WHRN
WNT7B
YWHAE
Entrez ID
6945
8573
HPRD ID
04278
02164
Ensembl ID
ENSG00000108788
ENSG00000147044
Uniprot IDs
Q9UH92
A0A2R8Y6F8
A0A2R8YE77
O14936
PDB IDs
1KGD
1KWA
1ZL8
3C0G
3C0H
3C0I
3MFR
3MFS
3MFT
3MFU
3TAC
6KMH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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