BTG1 and TUBA1A

Data Source:
BioGRID (two hybrid)

		BTG1	TUBA1A
Description		BTG anti-proliferation factor 1	tubulin alpha 1a
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus Cytoplasm Cytosol Microtubule Cytoplasmic Microtubule Microtubule Cytoskeleton Neuromuscular Junction Cytoplasmic Ribonucleoprotein Granule Myelin Sheath Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cytoskeleton-dependent Intracellular Transport Regulation Of Synapse Organization Cell Division Ciliary Basal Body-plasma Membrane Docking
Pathways		FOXO-mediated transcription of cell cycle genes	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs			Albendazole Vinblastine Mebendazole Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE Artenimol Phenethyl Isothiocyanate Colchiceine
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)	Brain morphology (MOSTest) ( 32665545) Composite immunoglobulin trait (IgG/IgM) ( 28628107)
Interacting Genes		16 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 FADD GRB2 HOXB9 NCK2 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6	63 interacting genes: ANXA7 ARL3 ATXN3 B4GALT1 BTG1 C8orf33 CDKN1A CDKN2A CEP20 CLIP1 CNP CPEB2 CXCR1 CYLD DAG1 DUSP23 EGFR EML1 GEMIN7 GRM7 GSK3B GZMB HDAC6 HTRA2 KEL KPNB1 LINC01554 LRRK2 MAP2 MAP7D3 MAPK6 MAPRE1 MAX MX1 MYC NFATC1 NUDT3 PAFAH1B1 PLA2G7 S100A8 S100A9 SDC3 SIAH1 SMN1 SNCA SOCS6 SOCS7 SPART STARD13 STK11 SYK TAOK2 TBCB TIMM17A TK1 TLN1 TTR TUBB UBE2D3 VAV1 VCL YWHAQ ZAP70
Entrez ID		694	7846
HPRD ID		15912	03959
Ensembl ID		ENSG00000133639	ENSG00000167552
Uniprot IDs		P62324 Q6IBC8	Q71U36
PDB IDs			5JCO 6J8F 6WSL 7C1M
Enriched GO Terms of Interacting Partners?
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