TCF4 and PRKAB2

Data Source:
BioGRID (two hybrid)

		TCF4	PRKAB2
Description		transcription factor 4	protein kinase AMP-activated non-catalytic subunit beta 2
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Beta-catenin-TCF7L2 Complex Beta-catenin-TCF Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TFIIB-class Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Identical Protein Binding Protein Heterodimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	AMP-activated Protein Kinase Activity Protein Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Nervous System Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Assembly	Protein Phosphorylation Fatty Acid Biosynthetic Process Carnitine Shuttle Cell Cycle Arrest Signal Transduction Macroautophagy Regulation Of Macroautophagy Regulation Of Fatty Acid Biosynthetic Process Regulation Of Catalytic Activity Regulation Of Primary Metabolic Process Positive Regulation Of Cold-induced Thermogenesis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Myogenesis Myogenesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Adenosine phosphate Acetylsalicylic acid Fostamatinib
Diseases		Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
GWAS		Ability to confide in someone ( 29970889) Adult body size ( 32376654) Adventurousness ( 30643258) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Automobile speeding propensity ( 30643258) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Broad depression or schizophrenia ( 30626913) Chin dimples ( 27182965) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal endothelial cell density ( 30894546) Corneal endothelial cell shape (percentage of hexagonally shaped cells) ( 30894546) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Depression ( 29700475) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 30224653) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling lonely ( 29500382) Feeling worry ( 29500382) Fuchs's corneal dystrophy ( 28358029 20825314) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431 29313844) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Intraocular pressure ( 29617998 31798171 29235454) Irritable mood ( 29500382) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Male-pattern baldness ( 28196072) Mental health study participation (completed survey) ( 31263887) Mood instability ( 31168069) Morning person ( 30696823) Neurociticism ( 29500382) Number of sexual partners ( 30643258) Obesity (early onset extreme) ( 23563609) Post bronchodilator FEV1/FVC ratio ( 26634245) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016) Pulse pressure ( 30578418) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 21926974 19571808 19571811 29483656 22688191 30285260 23974872 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403) Self-rated health ( 27864402) Self-reported risk-taking behaviour ( 30271922) Sleep duration (short sleep) ( 30846698) Social science traits (pleiotropy) (HIPO component 1) ( 30289880) Systolic blood pressure ( 30578418) Tea consumption ( 31046077) Type 2 diabetes ( 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		226 interacting genes: ALKBH4 AQP1 AR ARHGEF1 ARHGEF5 ARL16 ARMC7 ASAP3 ASCL1 ASCL3 ASCL4 ASPSCR1 ATG9A ATOH7 ATP11B ATP6V1B2 BACH1 BANF2 BCAS2 BCL2L15 BCL2L2 C1orf109 C1orf50 C1orf56 CABP5 CALM1 CALM2 CALM3 CBFA2T2 CCNH CDC37 CDC73 CDKN1A CDKN2C CFAP77 CHAF1A CHCHD2 CHIC2 CKS1B CLCNKA COA5 CPNE2 CTBP1 CTNNB1 DAXX DDX6 DEF6 DGCR6 DMRT3 DNTT DUSP23 DUSP29 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOC8 EXOSC1 FAH FAM110A FAM124B FAM74A4 FERD3L FIGLA FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 KLHL38 LASP1 LENG1 LGALS14 LHX4 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MARF1 MATN3 MEMO1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSGN1 MSRB3 MVP MYO15B MYO5B MYOD1 NCK2 NDOR1 NECTIN2 NEK6 NEK8 NEU4 NEUROD1 NEUROD4 NEUROG1 NEUROG3 NFAM1 NFKBID NHLH2 NME7 NMUR2 NOL9 NOXA1 NR2C2AP NR4A1 NUDT10 NUDT22 NXPE2 NXT2 OLFM3 ORC4 OSGIN1 OTUD4 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PRKN PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RAD51D RECK RELA REXO1L6P RNF6 RSPH14 RUNX1T1 SCOC SCX SDCBP SEC14L4 SGF29 SHFL SIGLEC6 SLC39A13 SLC4A1AP SMCP SMG9 SMOC1 SPATC1L SPG21 SPO11 SRSF2 STAMBPL1 STK16 STX11 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF23 TCF24 TCF3 TCL1A TLE1 TLE5 TMEM213 TP53 TRAPPC2L TRIM68 TRIML2 TSPOAP1 TSSC4 TSSK3 TSTD2 TTF2 TWIST1 TWIST2 TXNL4B UBASH3B UBE2I UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZMYND10 ZNF124 ZNF205-AS1 ZNF417 ZNF587 ZNF688	170 interacting genes: ABHD11 ADAMTSL4 ANAPC11 ARID5A AUNIP AVP BANP BEND5 BHLHB9 BLZF1 C11orf1 C19orf54 C2orf42 C3orf36 CALCOCO2 CASP2 CASP6 CCDC28B CCDC33 CDC14B CDSN CDX4 CFP CREB3L1 CRX CSNK2B CYSRT1 DAO DDAH2 DDIT4L DICER1 DOK3 DST ELL2 EPM2A ESM1 FDX1 FLNC GATA1 GATAD2B GCSAML GET4 GOLGA2 GOLGA6L9 GORASP2 GRAPL GRN GSC2 IHO1 IKZF1 IKZF3 IL37 IRAK1BP1 KATNBL1 KCTD5 KHDC4 KLF15 KRBOX4 KRT31 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-3 KRTAP4-12 KRTAP4-2 KRTAP4-5 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LHX3 LRIF1 LZTS1 LZTS2 MAGED1 MAJIN MDFI MEOX2 METTL27 MORN3 NAB2 NEBL NHLRC4 NUTM1 OXER1 PDE6G PDE6H PFDN5 PIAS2 PNMA1 PPP1R13B PPP1R16A PRDM14 PRKAA1 PRKAG1 PRKAG2 PSMD11 PSME3 PYGM QKI RAB3IP RACK1 RBM48 RBPMS REL RHEBL1 RIMBP3 RNF144B ROR2 RPH3AL SAMD4A SERTAD2 SMARCB1 SMUG1 SPRY1 SPRY2 SSC4D SSX2IP STX11 STX19 TADA2A TASOR2 TCF12 TCF19 TCF4 TCF7L2 TGM7 TLE5 TNNI1 TP53 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM14 TRIM35 TRIM42 TRIM54 TRIM55 TRIM63 TSR2 TTC23 UBXN11 USP54 VBP1 VPS28 WDR83 YPEL3 YY1AP1 ZBTB32 ZC2HC1C ZFP90 ZMYND19 ZNF177 ZNF236 ZNF474 ZNF526 ZNF559-ZNF177 ZNF581
Entrez ID		6925	5565
HPRD ID		03780	04117
Ensembl ID		ENSG00000196628	ENSG00000131791
Uniprot IDs		A0A024R2C0 A0A1B0GW91 A0A1B0GWD5 B3KVA4 E9PH57 H3BPJ7 H3BTP3 P15884	O43741
PDB IDs		2KWF 6OD3 6OD4 6OD5	2F15 2V8Q 2V92 2V9J 2Y8L 2Y8Q 2YA3 4CFH 4EAI 4EAJ 4RER 4REW 6B2E
Enriched GO Terms of Interacting Partners?
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