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TBXA2R and GNG2
Data Source:
BioGRID
(fluorescent resonance energy transfer)
TBXA2R
GNG2
Description
thromboxane A2 receptor
G protein subunit gamma 2
Image
GO Annotations
Cellular Component
Acrosomal Vesicle
Plasma Membrane
Integral Component Of Plasma Membrane
Nuclear Speck
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
G-protein Beta/gamma-subunit Complex
Extracellular Exosome
Molecular Function
Thromboxane A2 Receptor Activity
Guanyl-nucleotide Exchange Factor Activity
Protein Binding
Protein Binding
G-protein Beta-subunit Binding
Biological Process
Inflammatory Response
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Response To Nutrient
Positive Regulation Of Blood Coagulation
Response To Testosterone
Thromboxane A2 Signaling Pathway
Response To Drug
Response To Ethanol
Positive Regulation Of Angiogenesis
Positive Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Positive Regulation Of Smooth Muscle Contraction
Regulation Of Catalytic Activity
Cellular Response To Lipopolysaccharide
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Protein Folding
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Platelet Activation
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Catecholamine Stimulus
Pathways
Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptor
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Ridogrel
Seratrodast
Morniflumate
Halothane
Diseases
GWAS
Chronic obstructive pulmonary disease (
25584925
)
Cognitive decline rate in late mild cognitive impairment (
26252872
)
Craniofacial microsomia (
26853712
)
High density lipoprotein cholesterol levels (
29403010
)
Lung cancer (smoking interaction) (
24658283
)
Non-melanoma skin cancer (
23548203
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Triglyceride levels (
31170924
)
Triglyceride levels x loop diuretics use interaction (
31806883
)
Interacting Genes
35 interacting genes:
ADIPOR1
ARL6IP6
C5orf46
EMP1
GJB2
GNA11
GNA12
GNA13
GNAI2
GNAQ
GNAS
GNB1
GNG2
GPRASP1
GRK5
GRK6
MFSD5
MS4A13
NME2
NOX1
PRDX4
PRKCA
PSMA7
PSME3
PTGIR
RAB11A
RACK1
RAF1
RPGRIP1L
SLC35B4
SLC41A1
TM4SF4
VRK2
YWHAZ
ZDHHC15
17 interacting genes:
ADCY2
ADRA2A
ADRB2
AVPR2
BTK
CACNA1H
CHRM2
GNAI1
GNB1
GNB3
GNB4
GNB5
MRGPRX1
PGGT1B
PLEKHG2
SMURF2
TBXA2R
Entrez ID
6915
54331
HPRD ID
01768
16234
Ensembl ID
ENSG00000006638
ENSG00000186469
Uniprot IDs
P21731
Q05C92
Q0VAB0
P59768
PDB IDs
1LBN
4KFM
5HE0
5HE1
5HE2
5HE3
5UKK
5UKL
5UKM
5UZ7
6B3J
6CRK
6D9H
6DDE
6DDF
6E3Y
6EG8
6G79
6GDG
6K41
6K42
6KPF
6KPG
6LFM
6LFO
6LI3
6LMK
6LML
6M1H
6M1I
6M8S
6N4B
6NI3
6NIY
6OIJ
6OIK
6OMM
6ORV
6OS9
6OSA
6OT0
6P9X
6P9Y
6PB0
6PB1
6PT0
6UUN
6UUS
6UVA
6VCB
6VMS
6VN7
6WHA
6WHC
6WI9
6WPW
6WWZ
6WZG
6X18
6X19
6X1A
6XBJ
6XBK
6XBL
6XBM
7C2E
7CFM
7CFN
7K7L
7K7Z
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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