TBCD and ARL2

Data Source:
HPRD (in vitro, in vivo)

		TBCD	ARL2
Description		tubulin folding cofactor D	ADP ribosylation factor like GTPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Adherens Junction Bicellular Tight Junction Lateral Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Intermembrane Space Mitochondrial Matrix Golgi Apparatus Centrosome Cytosol Focal Adhesion Cilium Microtubule Cytoskeleton Lateral Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Beta-tubulin Binding Chaperone Binding	GTPase Activity GTPase Inhibitor Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Protein Folding Tubulin Complex Assembly Post-chaperonin Tubulin Folding Pathway Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Microtubule Polymerization Adherens Junction Assembly Positive Regulation Of GTPase Activity Cell Morphogenesis Involved In Neuron Differentiation Bicellular Tight Junction Assembly	Tubulin Complex Assembly Centrosome Cycle Positive Regulation Of Cell-substrate Adhesion Regulation Of Microtubule Polymerization Positive Regulation Of Microtubule Polymerization Negative Regulation Of GTPase Activity Regulation Of Insulin Secretion Maintenance Of Protein Location In Nucleus Bicellular Tight Junction Assembly
Pathways		Post-chaperonin tubulin folding pathway	Post-chaperonin tubulin folding pathway Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane RAS processing
Drugs			Tagraxofusp
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Bone mineral accretion in asthma (oral corticosteroid dose interaction) ( 26025128) Mean platelet volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Response to cognitive-behavioural therapy in anxiety and major depressive disorders ( 31123309)
Interacting Genes		13 interacting genes: ACD APP ARL2 DEXI MTDH MTNR1B POLR2I POT1 SMAD9 TBCE TERF1 TUBB XRCC6	6 interacting genes: ARL2BP LHX4 PDE6D TBCD TBL1XR1 UNC119
Entrez ID		6904	402
HPRD ID		05227	11869
Ensembl ID		ENSG00000141556	ENSG00000213465
Uniprot IDs		Q9BTW9	P36404 Q53YD8
PDB IDs			3DOE 3DOF
Enriched GO Terms of Interacting Partners?
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