TARS1 and NDRG1

Data Source:
HPRD (in vivo)

		TARS1	NDRG1
Description		threonyl-tRNA synthetase 1	N-myc downstream regulated 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	TRNA Binding Threonine-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Protein Binding Microtubule Binding Small GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Threonyl-tRNA Aminoacylation	Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Regulation Of Apoptotic Process Mast Cell Activation Cellular Response To Hypoxia Postsynapse Organization
Pathways		Cytosolic tRNA aminoacylation	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Drugs		Threonine
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Estimated glomerular filtration rate ( 31015462) Left-handedness ( 32989287) Nontyphoidal Salmonella bacteraemia ( 29523850) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Interacting Genes		7 interacting genes: BRCA1 C7orf25 HARS1 HSPB1 LINC01554 NDRG1 TARS3	70 interacting genes: ACSL3 ACTG1 AP1M2 AP2M1 APOA1 APOA2 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN GSK3B HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME MYC NCL NR4A1 PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RTN1 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS1 TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		6897	10397
HPRD ID		01762	05586
Ensembl ID		ENSG00000113407	ENSG00000104419
Uniprot IDs		P26639	B3KWB2 Q8N959 Q92597
PDB IDs		1WWT 4HWT 4P3N 4TTV 5XLN
Enriched GO Terms of Interacting Partners?
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