KLF5 and PARP1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		KLF5	PARP1
Description		Kruppel like factor 5	poly(ADP-ribose) polymerase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex Golgi Apparatus Intracellular Membrane-bounded Organelle	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Nucleolus Mitochondrion Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Site Of DNA Damage
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding MRF Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Binding RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Estrogen Receptor Binding Identical Protein Binding Histone Deacetylase Binding Protein N-terminus Binding NAD Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Skeletal Muscle Satellite Cell Differentiation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Myotube Differentiation Involved In Skeletal Muscle Regeneration Microvillus Assembly Regulation Of Microvillus Assembly Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Intestinal Epithelial Cell Development Positive Regulation Of Transcription By Transcription Factor Localization Cellular Response To Organic Cyclic Compound Cell-cell Signaling Via Exosome Cellular Response To Peptide Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Transcription By RNA Polymerase II Protein ADP-ribosylation Apoptotic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of SMAD Protein Complex Assembly Protein Autoprocessing Peptidyl-serine ADP-ribosylation Peptidyl-glutamic Acid Poly-ADP-ribosylation Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleotide-excision Repair, DNA Incision Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process DNA Damage Response, Detection Of DNA Damage Mitochondrial DNA Repair Regulation Of DNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Global Genome Nucleotide-excision Repair Cellular Response To Zinc Ion Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Neuron Death Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Single Strand Break Repair Regulation Of Cellular Protein Localization Response To Aldosterone Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Generation From Poly-ADP-D-ribose Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of ATP Biosynthetic Process
Pathways		Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis	POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29679657) Blood urea nitrogen levels ( 31152163) Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast Cancer in BRCA1 mutation carriers ( 29058716) Chronotype ( 30696823) Colorectal cancer ( 30529582) Colorectal cancer or advanced adenoma ( 30510241) Creatine kinase levels ( 29403010) Endometrial cancer ( 30093612 27008869) Endometrial cancer (endometrioid histology) ( 30093612) Intraocular pressure ( 29785010 31959993) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Pancreatic cancer ( 29422604 20101243 26098869 25086665) Prostate cancer ( 31562322 26443449) Systolic blood pressure ( 30224653) Type 2 diabetes ( 25760438)	Coronary artery disease ( 29212778) Leukocyte telomere length ( 32109421 31171785) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 32341527 30429480) Platelet count ( 29403010) Telomere length ( 29151059)
Interacting Genes		27 interacting genes: ANP32B ATXN3L BAP1 CREBBP EP300 ESR1 FBXW7 GSK3B GTF2B GTF2E2 GTF2F2 HDAC1 JUN NCOR1 NCOR2 NFKB1 PARP1 PPARG PRKCA PRKCD RARA RXRA SET SMURF2 TBP UBE2I WWP1	105 interacting genes: APTX ATM BCL2 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTCF CTSB CTSG DTX2 DUX4 E2F1 ERCC6 ERG ETS1 FOXO1 GTF2F1 GZMB GZMM H1-0 H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-3A H3-4 H3C1 H4C3 HDAC1 HDAC3 HIPK2 HMGA1 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LZTR1 MACROH2A1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF144A RNF168 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 UBE2I WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423
Entrez ID		688	142
HPRD ID		04212	01435
Ensembl ID		ENSG00000102554	ENSG00000143799
Uniprot IDs		Q13887 Q5T6X2	A0A024R3T8 P09874
PDB IDs		2EBT	1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW
Enriched GO Terms of Interacting Partners?
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