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SYK and FCRL3
Data Source:
BioGRID
(pull down)
SYK
FCRL3
Description
spleen associated tyrosine kinase
Fc receptor like 3
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
B Cell Receptor Complex
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Early Phagosome
Protein-containing Complex
T Cell Receptor Complex
Integral Component Of Plasma Membrane
Cell Surface
Molecular Function
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Integrin Binding
Protein Binding
ATP Binding
Interleukin-15 Receptor Binding
Protein Kinase Binding
Phosphatase Binding
Toll-like Receptor Binding
SH2 Domain Binding
Transmembrane Signaling Receptor Activity
Kinase Binding
Phosphatase Binding
Protein Phosphatase Binding
Protein Tyrosine Kinase Binding
Biological Process
Angiogenesis
Lymph Vessel Development
Positive Regulation Of Receptor Internalization
Stimulatory C-type Lectin Receptor Signaling Pathway
Adaptive Immune Response
Macrophage Activation Involved In Immune Response
Neutrophil Activation Involved In Immune Response
Leukocyte Activation Involved In Immune Response
Serotonin Secretion By Platelet
Protein Phosphorylation
Protein Import Into Nucleus
Leukocyte Cell-cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Integrin-mediated Signaling Pathway
Activation Of JUN Kinase Activity
Animal Organ Morphogenesis
Regulation Of Platelet Activation
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Leukotriene Biosynthetic Process
Cell Differentiation
Platelet Activation
Neutrophil Chemotaxis
Positive Regulation Of Protein-containing Complex Assembly
Receptor Internalization
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-3 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Superoxide Anion Generation
Positive Regulation Of Superoxide Anion Generation
Positive Regulation Of Cell Adhesion Mediated By Integrin
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Interleukin-2-mediated Signaling Pathway
Interleukin-3-mediated Signaling Pathway
Defense Response To Bacterium
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
Regulation Of Neutrophil Degranulation
Beta Selection
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Positive Regulation Of Bone Resorption
Positive Regulation Of Alpha-beta T Cell Differentiation
Positive Regulation Of Alpha-beta T Cell Proliferation
Blood Vessel Morphogenesis
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Phagocytosis
Positive Regulation Of Calcium-mediated Signaling
B Cell Receptor Signaling Pathway
Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Killing Of Cells Of Other Organism
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Molecule Of Fungal Origin
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Arachidonic Acid Secretion
Regulation Of Platelet Aggregation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Immunoglobulin Production
Cell Surface Receptor Signaling Pathway
Positive Regulation Of B Cell Proliferation
Regulation Of Toll-like Receptor 9 Signaling Pathway
Positive Regulation Of MAPK Cascade
Regulation Of B Cell Differentiation
Negative Regulation Of B Cell Receptor Signaling Pathway
Regulation Of B Cell Activation
Regulation Of Calcium Ion Import
Positive Regulation Of Protein Serine/threonine Phosphatase Activity
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Integrin signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Dectin-2 family
Interleukin-2 signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
FLT3 signaling through SRC family kinases
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Staurosporine
N-(2-hydroxy-1,1-dimethylethyl)-1-methyl-3-(1H-pyrrolo[2,3-b]pyridin-2-yl)-1H-indole-5-carboxamide
Tamatinib
2-{2-[(3,5-dimethylphenyl)amino]pyrimidin-4-yl}-N-[(1S)-2-hydroxy-1-methylethyl]-4-methyl-1,3-thiazole-5-carboxamide
2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(3-methylphenyl)amino]pyrimidine-5-carboxamide
Ellagic acid
Fostamatinib
Diseases
GWAS
Alzheimer's disease (
30636644
)
Anti-saccade response (
29064472
)
Atrial fibrillation (
28416822
)
Chromosomal aberration frequency (total) (
31586183
)
Frontal pole volume (
31530798
)
Mean platelet volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Multiple sclerosis (
21833088
)
Multiple sclerosis and HDL levels (pleiotropy) (
26920376
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
27863252
)
Plateletcrit (
32888494
)
Type 2 diabetes (
22456796
)
Vascular dementia (
23480133
)
Blood protein levels (
30072576
29875488
28240269
)
Graves' disease (
21841780
)
IgA nephropathy (
26028593
)
Insulinoma-associated antigen 2 autoantibody levels in type 1 diabetes (
21829393
)
Multiple sclerosis (
31604244
21833088
)
Multiple sclerosis and LDL levels (pleiotropy) (
26920376
)
Rheumatoid arthritis (
30423114
24390342
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Selective IgA deficiency (
27723758
)
Interacting Genes
107 interacting genes:
APP
AR
BLNK
BTK
CALM1
CBL
CBLB
CD19
CD22
CD3E
CD72
CD79A
CD79B
COASY
CRKL
CSF2RB
CSF3R
CTTN
DBNL
DPP9
DUSP3
EGFR
EPOR
ERBB2
ERBB3
ERBB4
FCER1G
FCGR1A
FCGR2A
FCGR3A
FCRL3
FGR
FYN
GAB1
GAB2
GRB2
HCLS1
HDAC1
HDAC2
HDAC3
HDAC4
HDAC6
HDAC9
HGS
HNRNPU
IL15RA
IL2RB
ITGB2
JAK1
KIT
LAT
LAX1
LCK
LCP2
LYN
MAP4K1
MAPK3
MAPT
MET
MS4A2
NEDD4
NFAM1
PAG1
PIK3AP1
PIK3R1
PIK3R2
PLCG1
PLCG2
POU2AF1
PRKCA
PRKD1
PTK2
PTK2B
PTPN6
PXN
RASA1
RHOU
RPS10
RPS6KA1
RPS6KB1
RPS6KB2
SELPLG
SH2B2
SH2D2A
SH3BP2
SHC1
SIT1
SLA
SLC4A1
SNCA
SRC
STAT1
STAT3
STAT5A
TERF1
TLR4
TNFRSF1A
TRAF6
TRIM15
TUBA1A
TUBA4A
TYROBP
UBASH3B
UBB
USP25
VAV1
VAV2
11 interacting genes:
AGPAT4
CMTM5
IGFBP5
MS4A1
PTPN11
PTPN6
SLC2A5
SLC30A3
STATH
SYK
ZAP70
Entrez ID
6850
115352
HPRD ID
02514
07352
Ensembl ID
ENSG00000165025
ENSG00000160856
Uniprot IDs
A0A024R244
A0A024R273
P43405
Q96P31
PDB IDs
1A81
1CSY
1CSZ
1XBA
1XBB
1XBC
3BUW
3EMG
3FQE
3FQH
3FQS
3SRV
3TUB
3TUC
3TUD
3VF8
3VF9
4DFL
4DFN
4F4P
4FL1
4FL2
4FL3
4FYN
4FYO
4FZ6
4FZ7
4GFG
4I0R
4I0S
4I0T
4PUZ
4PV0
4PX6
4RSS
4RX7
4RX8
4RX9
4WNM
4XG2
4XG3
4XG4
4XG6
4XG7
4XG8
4XG9
4YJO
4YJP
4YJQ
4YJR
4YJS
4YJT
4YJU
4YJV
5C26
5C27
5CXH
5CXZ
5CY3
5GHV
5LMA
5LMB
5T68
5TIU
5TR6
5TT7
5Y5T
5Y5U
6HM6
6HM7
6SSB
6VOV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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