SUPT5H and PPP2R2D

Data Source:
HPRD (two hybrid)

		SUPT5H	PPP2R2D
Description		SPT5 homolog, DSIF elongation factor subunit	protein phosphatase 2 regulatory subunit Bdelta
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm DSIF Complex	Protein Phosphatase Type 2A Complex Cytosol
	Molecular Function	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Viral Transcription Negative Regulation Of MRNA Polyadenylation	Mitotic Cell Cycle Exit From Mitosis Regulation Of Phosphoprotein Phosphatase Activity Cell Division Peptidyl-serine Dephosphorylation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE	MASTL Facilitates Mitotic Progression
Drugs
Diseases
GWAS		Neutrophil count ( 32888494) White blood cell count ( 32888494)	Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Chronotype ( 30696823) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		45 interacting genes: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CEP55 CSNK2A1 DBN1 DCAF6 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B	3 interacting genes: DAPK1 PTTG1 SUPT5H
Entrez ID		6829	55844
HPRD ID		03655	15172
Ensembl ID		ENSG00000196235	ENSG00000175470
Uniprot IDs		O00267	Q66LE6 Q6IN90
PDB IDs		2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED
Enriched GO Terms of Interacting Partners?
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