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SUPT4H1 and XRCC5
Data Source:
HPRD
(in vivo, in vitro)
SUPT4H1
XRCC5
Description
SPT4 homolog, DSIF elongation factor subunit
X-ray repair cross complementing 5
Image
GO Annotations
Cellular Component
Nucleoplasm
DSIF Complex
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Plasma Membrane
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Secretory Granule Lumen
Ku70:Ku80 Complex
Nonhomologous End Joining Complex
Site Of DNA Damage
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Complex Binding
Protein Binding
Zinc Ion Binding
Protein Heterodimerization Activity
Transcription Regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA Helicase Activity
Damaged DNA Binding
Double-stranded DNA Binding
Double-stranded Telomeric DNA Binding
RNA Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Enzyme Activator Activity
DNA-dependent ATPase Activity
Ubiquitin Protein Ligase Binding
U3 SnoRNA Binding
Telomeric DNA Binding
Protein-containing Complex Binding
DNA End Binding
5'-deoxyribose-5-phosphate Lyase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription, DNA-templated
Transcription By RNA Polymerase II
Transcription Elongation From RNA Polymerase II Promoter
MRNA Processing
Negative Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Viral Transcription
Telomere Maintenance
Activation Of Innate Immune Response
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Recombination
Cellular Response To DNA Damage Stimulus
Brain Development
Cell Population Proliferation
Regulation Of Telomere Maintenance
Positive Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Type I Interferon Production
DNA Duplex Unwinding
Small-subunit Processome Assembly
Response To Drug
Positive Regulation Of Catalytic Activity
Neutrophil Degranulation
Innate Immune Response
Positive Regulation Of Protein Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Neurogenesis
Positive Regulation Of Telomerase Activity
Hematopoietic Stem Cell Differentiation
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Fatty Acid
Cellular Hyperosmotic Salinity Response
Cellular Response To Gamma Radiation
Cellular Response To X-ray
Establishment Of Integrated Proviral Latency
Negative Regulation Of T-circle Formation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Pausing and recovery of Tat-mediated HIV elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
Tat-mediated HIV elongation arrest and recovery
Tat-mediated elongation of the HIV-1 transcript
HIV elongation arrest and recovery
Pausing and recovery of HIV elongation
RNA Polymerase II Pre-transcription Events
TP53 Regulates Transcription of DNA Repair Genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Transcription Elongation
2-LTR circle formation
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
Neutrophil degranulation
Drugs
Diseases
GWAS
Eosinophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Refractive error (
32231278
)
Interacting Genes
11 interacting genes:
ANXA5
APP
EWSR1
HTATSF1
LRIF1
LRRK2
MFHAS1
NSG2
PDLIM1
SUPT5H
XRCC5
59 interacting genes:
APEX1
AR
ATM
ATR
BAZ1A
BRCA1
CD40
CDC16
CEBPA
CHAF1A
COIL
CSNK2A1
DUX4
ELF3
ERCC6
GZMA
GZMB
HSF1
HSPB1
LIG3
LINC01554
MSX2
NAA15
NBN
NCOA6
NDRG1
ORC2
PARP1
PCNA
PDX1
PGR
POLA1
POLD1
POLE
POLR2A
PRKDC
PTEN
RBM14
RNF126
RUNX2
SGO1
SRPK2
SUMO2
SUPT4H1
SUPT5H
TCF4
TERF2IP
TERT
TOP1
TOP2B
TYK2
UBC
UBE2I
UCHL3
VAV1
WRN
XRCC6
ZBTB7A
ZRANB1
Entrez ID
6827
7520
HPRD ID
16026
08935
Ensembl ID
ENSG00000213246
ENSG00000079246
Uniprot IDs
P63272
P13010
PDB IDs
3H7H
5OIK
6GMH
6GML
6TED
1JEQ
1JEY
1Q2Z
1RW2
3RZ9
5Y3R
6ERF
6ERG
6ERH
6ZH6
6ZHA
6ZHE
Enriched GO Terms of Interacting Partners
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