AURKA and BTK

Data Source:
BioGRID (pull down)

		AURKA	BTK
Description		aurora kinase A	Bruton tyrosine kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Centriole Spindle Cytosol Spindle Microtubule Cilium Microtubule Cytoskeleton Midbody Spindle Pole Centrosome Chromosome Passenger Complex Germinal Vesicle Axon Hillock Pronucleus Perinuclear Region Of Cytoplasm Spindle Midzone Meiotic Spindle Mitotic Spindle Pole	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Histone Serine Kinase Activity Protein Heterodimerization Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Identical Protein Binding Metal Ion Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Spindle Organization Mitotic Spindle Organization Spindle Assembly Involved In Female Meiosis I Mitotic Centrosome Separation Response To Wounding Anterior/posterior Axis Specification Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Stability Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Histone-serine Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Centrosome Cycle Protein Autophosphorylation Cell Division Centrosome Localization Protein Localization To Centrosome Liver Regeneration Positive Regulation Of Oocyte Maturation Regulation Of Signal Transduction By P53 Class Mediator Neuron Projection Extension	Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Negative Regulation Of Cytokine Production Adaptive Immune Response B Cell Affinity Maturation Histamine Secretion By Mast Cell Regulation Of B Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of B Cell Apoptotic Process Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Mesoderm Development Peptidyl-tyrosine Phosphorylation Calcium-mediated Signaling Negative Regulation Of B Cell Proliferation Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway B Cell Activation Innate Immune Response Positive Regulation Of B Cell Differentiation Protein Autophosphorylation Cell Maturation B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Molecule Of Fungal Origin Apoptotic Signaling Pathway Cellular Response To Interleukin-7
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA replication proteins TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Phosphonothreonine AT9283 CYC116 Alisertib SNS-314 Cenisertib Enzastaurin 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE AKI-001 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE Fostamatinib MLN8054	Dasatinib Inositol 1,3,4,5-Tetrakisphosphate XL418 Ibrutinib Acalabrutinib Fostamatinib Zanubrutinib Abivertinib
Diseases			Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8 Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		170 interacting genes: AATF AKT1 ANGPTL4 ANP32B APP ARPC1B ARPC2 ATRX AUNIP AURKAIP1 BAAT BCL2L1 BEX2 BIRC5 BLID BORA BRAF BRCA1 BTK CBX3 CCND2 CCNE1 CDC20 CDC25B CDH13 CDK8 CHFR CKAP5 CORO2A CSN2 CTCFL CYLC2 DACH1 DKK3 EHMT2 EPHA2 EPSTI1 ERBB2 ERRFI1 FANCA FBP2 FOXF1 FOXP1 FZR1 GADD45A GMNN GSK3B GTF3C4 H3-4 H3C1 HDAC2 HDAC6 HEMGN HIF1A HNRNPF HNRNPK IFI16 IGFBP3 IKBKB INCENP KIF11 KIF2C KLHL18 KLK5 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP3K5 MAPK3 MAPRE2 MAPRE3 MBD3 MBP MDM2 MED26 MTA3 MYC MYT1 MYT1L NANS NAT2 NDC80 NEDD9 NF2 NFKBIA NFXL1 NIN NKX1-1 NME1 NSD2 NUF2 OTUB1 OTUD7B PARP10 PAX4 PAX8 PDGFRA PDLIM2 PLK3 PML POU4F3 PPP1CA PPP1CB PPP1CC PPP2CB PPP3R2 PRKACA PSEN2 PSMC3IP PTPRD PTTG1 PUM2 RASA1 RASSF1 RELA REST S100A14 SCGB3A1 SEC61B SFRP4 SIN3B SOX18 SOX3 SOX30 SOX4 SREBF2 SRPK1 SRPK2 SSRP1 STAT2 STK11 STX17 SUPT20H SWT1 TACC1 TACC3 TBC1D2 TBX10 TCEAL2 TCERG1 TCF3 TEAD2 TFAP2B TGFB1 THRSP TLK1 TLK2 TP53 TP73 TPX2 TRMO TRRAP TSC1 TSTD2 UBE2C UBE2I UBE2N UBTF USP2 USP21 VHL WIF1 XPA YY1 ZFHX3 ZKSCAN2 ZNF189 ZNF510	76 interacting genes: ABL1 APP AR ARHGAP17 ARID3A ARRB1 AURKA BCL2L11 BECN1 BLNK BMX CAV1 CBL CD19 CMTM3 COASY DAPP1 ERBB3 EWSR1 FAS FASLG FYN GAB1 GNA12 GNAQ GNG2 GTF2I HCK IBTK IRAK1 ITK JAK1 KHDRBS1 KIT LYN MDM2 MEOX2 MET MRPS22 MYD88 PIK3AP1 PIK3R3 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLAU PLCG1 PLCG2 PRKCA PRKCB PRKCE PRKCQ PRKCZ PRKD1 RELA RPS6KB1 RPS6KB2 SH2B2 SH3BP5 SMURF1 STAT5A SYK TEC TIRAP TLR4 TLR6 TLR8 TLR9 TNFRSF10A TP53 VAV1 WAS WASF2
Entrez ID		6790	695
HPRD ID		04066	02248
Ensembl ID		ENSG00000087586	ENSG00000010671
Uniprot IDs		O14965	Q06187 Q5JY90
PDB IDs		1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2DWB 2J4Z 2J50 2NP8 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG 2XRU 3COH 3E5A 3EFW 3FDN 3H0Y 3H0Z 3H10 3HA6 3K5U 3LAU 3M11 3MYG 3NRM 3O50 3O51 3P9J 3QBN 3R21 3R22 3UNZ 3UO4 3UO5 3UO6 3UOD 3UOH 3UOJ 3UOK 3UOL 3UP2 3UP7 3VAP 3W10 3W16 3W18 3W2C 4B0G 4BN1 4BYI 4BYJ 4C3P 4C3R 4CEG 4DEA 4DEB 4DED 4DEE 4DHF 4J8M 4J8N 4JAI 4JAJ 4JBO 4JBP 4JBQ 4O0S 4O0U 4O0W 4PRJ 4UYN 4UZD 4UZH 4ZS0 4ZTQ 4ZTR 4ZTS 5AAD 5AAE 5AAF 5AAG 5DN3 5DNR 5DOS 5DPV 5DR2 5DR6 5DR9 5DRD 5DT0 5DT3 5DT4 5EW9 5G15 5G1X 5L8J 5L8K 5L8L 5LXM 5OBJ 5OBR 5ODT 5ONE 5ORL 5ORN 5ORO 5ORP 5ORR 5ORS 5ORT 5ORV 5ORW 5ORX 5ORY 5ORZ 5OS0 5OS1 5OS2 5OS3 5OS4 5OS5 5OS6 5OSD 5OSE 5OSF 5ZAN 6C2R 6C2T 6C83 6CPE 6CPF 6CPG 6GRA 6HJJ 6HJK 6I2U 6R49 6R4A 6R4B 6R4C 6R4D 6VPG 6VPH 6VPI 6VPJ 6VPL 6VPM 6XKA 6Z4Y	1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P 3GEN 3K54 3OCS 3OCT 3P08 3PIX 3PIY 3PIZ 3PJ1 3PJ2 3PJ3 4NWM 4OT5 4OT6 4OTF 4OTQ 4OTR 4RFY 4RFZ 4RG0 4RX5 4YHF 4Z3V 4ZLY 4ZLZ 5BPY 5BQ0 5FBN 5FBO 5J87 5JRS 5KUP 5P9F 5P9G 5P9H 5P9I 5P9J 5P9K 5P9L 5P9M 5T18 5U9D 5VFI 5VGO 5XYZ 5ZZ4 6AUA 6AUB 6BIK 6BKE 6BKH 6BKW 6BLN 6DI0 6DI1 6DI3 6DI5 6DI9 6E4F 6EP9 6HRP 6HRT 6HTF 6J6M 6N9P 6NFH 6NFI 6NZM 6O8I 6OMU 6S90 6TFP 6X3N 6X3O 6X3P 6XE4
Enriched GO Terms of Interacting Partners?
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