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SREBF1 and MED1
Data Source:
BioGRID
(pull down)
SREBF1
MED1
Description
sterol regulatory element binding transcription factor 1
mediator complex subunit 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
Integral Component Of Membrane
Protein-containing Complex
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Membrane
Mediator Complex
Protein-DNA Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Protein Kinase Binding
Sterol Response Element Binding
Protein-containing Complex Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Transcription Coregulator Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Nuclear Receptor Binding
Estrogen Receptor Binding
Nuclear Receptor Coactivator Activity
Chromatin DNA Binding
Nuclear Hormone Receptor Binding
Vitamin D Receptor Binding
Retinoic Acid Receptor Binding
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Thyroid Hormone Receptor Binding
LBD Domain Binding
Ubiquitin Protein Ligase Activity
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Heart Rate By Chemical Signal
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Aging
Circadian Rhythm
Cholesterol Metabolic Process
Insulin Receptor Signaling Pathway
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Glucose
Positive Regulation Of Triglyceride Biosynthetic Process
Lipid Localization
Regulation Of Lipid Storage
Regulation Of Fatty Acid Metabolic Process
Lung Development
Intracellular Receptor Signaling Pathway
Positive Regulation Of Histone Deacetylation
Regulation Of Protein Stability
Response To Food
Response To Retinoic Acid
Response To Progesterone
SREBP Signaling Pathway
Response To Glucagon
Response To Drug
MRNA Transcription By RNA Polymerase II
Fat Cell Differentiation
Response To Ethanol
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Insulin Secretion
Response To CAMP
Cellular Response To Fatty Acid
Regulation Of Autophagy Of Mitochondrion
Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Angiogenesis
Liver Development
Embryonic Placenta Development
Lens Development In Camera-type Eye
Thyroid Hormone Mediated Signaling Pathway
Ventricular Trabecula Myocardium Morphogenesis
Retinal Pigment Epithelium Development
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Thyroid Hormone Generation
Protein Import Into Nucleus
Androgen Biosynthetic Process
Brain Development
Lactation
Positive Regulation Of Gene Expression
Negative Regulation Of Keratinocyte Proliferation
Protein Ubiquitination
Regulation Of Lipid Metabolic Process
Keratinocyte Differentiation
Monocyte Differentiation
Intracellular Steroid Hormone Receptor Signaling Pathway
Animal Organ Regeneration
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Embryonic Heart Tube Development
Embryonic Hindlimb Morphogenesis
Embryonic Hemopoiesis
Peroxisome Proliferator Activated Receptor Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Megakaryocyte Development
MRNA Transcription By RNA Polymerase II
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Keratinocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Erythrocyte Development
Enucleate Erythrocyte Development
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Mammary Gland Branching Involved In Thelarche
Mammary Gland Branching Involved In Pregnancy
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Positive Regulation Of G0 To G1 Transition
Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Thyroid Hormone Stimulus
Positive Regulation Of Hepatocyte Proliferation
Regulation Of RNA Biosynthetic Process
Pathways
RORA activates gene expression
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
Estrogen-dependent gene expression
Drugs
Doconexent
Omega-3-acid ethyl esters
Omega-3 fatty acids
Fish oil
Becocalcidiol
Diseases
GWAS
Coffee consumption (
31046077
)
Eosinophil counts (
32888494
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Parkinson's disease (
21738487
)
Resting heart rate (
27798624
)
Schizophrenia (
28991256
25056061
29483656
)
TB-LM or TBLH-BMD (pleiotropy) (
28743860
)
White blood cell count (
32888494
)
Asthma (
31619474
)
Creatinine levels (
29403010
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (
29403010
)
Lung function (FVC) (
30061609
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
24390342
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Systemic lupus erythematosus (
24871463
)
Ulcerative colitis (
20228799
)
Interacting Genes
40 interacting genes:
AR
ATXN1
ATXN1L
CDK8
CREBBP
EP300
ESR1
ESR2
FBXW7
GSK3B
HNF4A
ID2
ID3
KLF13
LMNA
MAPK1
MAPK3
MED1
MED12
MED13
MED14
MED17
MED23
MED24
MED25
MED26
MED6
MED7
MTNR1B
NR0B1
NR5A2
PLK1
PRMT5
SMARCD3
SP1
SUMO1
TWIST2
UBE2I
YY1
ZBTB7C
46 interacting genes:
AKAP9
AR
BRCA1
CASK
CTDP1
ESR1
ESR2
EZH2
GABPA
GATA1
GATA3
GATA4
GATA6
GJB5
HNF4A
KIF1A
MAPK3
MDM2
MED12
MED14
MED25
MED8
MED9
MYC
NCOA6
NR1H2
NR1I3
NR3C1
NR4A1
PIN1
PPARA
PPARG
PPARGC1A
RARA
RBM5
RORA
RPA2
RXRA
SREBF1
TET2
THRA
THRB
TP53
VDR
YWHAH
YWHAQ
Entrez ID
6720
5469
HPRD ID
01701
05055
Ensembl ID
ENSG00000072310
ENSG00000125686
Uniprot IDs
A8MTU8
B3KR77
P36956
Q15648
PDB IDs
1AM9
1RJK
1RK3
1RKG
1RKH
2O4J
2O4R
2ZFX
3A2H
3AUN
3VJS
3VJT
3VRT
3VRU
3VRV
3VRW
3W0G
3W0H
3W0I
3W0J
3W5P
3W5Q
3W5R
3W5T
3WT5
3WT6
3WT7
3WTQ
4YNK
5AWJ
5AWK
5B41
5B5B
5GIC
5GID
5GIE
5XPM
5XPN
5XPO
5XPP
5XUQ
5XZF
5XZH
5ZWE
5ZWF
5ZWH
5ZWI
6D94
6JEZ
6K5O
6ONJ
Enriched GO Terms of Interacting Partners
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