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SRI and PDE4C
Data Source:
BioGRID
(two hybrid)
SRI
PDE4C
Description
sorcin
phosphodiesterase 4C
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Cytosol
Membrane
Sarcoplasmic Reticulum
Z Disc
T-tubule
Sarcoplasmic Reticulum Membrane
Chromaffin Granule Membrane
Axon Terminus
Dendritic Spine Neck
Extracellular Exosome
Extracellular Space
Nucleus
Cytosol
Cilium
Perinuclear Region Of Cytoplasm
Molecular Function
Protease Binding
Signaling Receptor Binding
Calcium Channel Regulator Activity
Calcium Ion Binding
Protein Binding
Ion Channel Binding
Protein Heterodimerization Activity
Repressing Transcription Factor Binding
3',5'-cyclic-nucleotide Phosphodiesterase Activity
3',5'-cyclic-AMP Phosphodiesterase Activity
Metal Ion Binding
Biological Process
Action Potential
Calcium Ion Transport
Intracellular Sequestering Of Iron Ion
Regulation Of Striated Muscle Contraction
Signal Transduction
Heart Development
Muscle Organ Development
Regulation Of Heart Contraction
Negative Regulation Of Heart Rate
Regulation Of Cell Communication By Electrical Coupling
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Cytoplasmic Sequestering Of Transcription Factor
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Regulation Of Calcium Ion Transport
Negative Regulation Of Cardiac Muscle Contraction
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Regulation Of Cardiac Muscle Cell Contraction
Regulation Of Relaxation Of Muscle
Regulation Of High Voltage-gated Calcium Channel Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Negative Regulation Of Transcription Regulatory Region DNA Binding
CAMP Catabolic Process
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Pathways
Stimuli-sensing channels
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Ion homeostasis
Ion transport by P-type ATPases
DARPP-32 events
G alpha (s) signalling events
Drugs
Calcium citrate
Calcium Phosphate
Calcium phosphate dihydrate
Caffeine
Dyphylline
Iloprost
Amrinone
Roflumilast
Piclamilast
Crisaborole
Ibudilast
Exisulind
Trapidil
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Urate levels (
31578528
)
Interacting Genes
20 interacting genes:
ALG2
ANXA11
ANXA7
CACNA1C
CACNA1S
CALCOCO2
GCA
MTNR1A
NRAS
PDE4C
PRR13
PSEN2
RYR2
SHBG
SMAD2
SNCA
SRPK2
STAT3
TCF12
USHBP1
9 interacting genes:
DDIT4L
GSC2
KLRK1
MEOX1
MEOX2
OSGIN1
PAX6
SRI
ZNF280A
Entrez ID
6717
5143
HPRD ID
01680
02529
Ensembl ID
ENSG00000075142
ENSG00000105650
Uniprot IDs
B4DHQ6
C9J0K6
P30626
O43849
P78505
Q08493
Q32MM7
Q7KYS4
PDB IDs
1JUO
2JC2
4U8D
4UPG
4USL
5MRA
1LXU
2QYM
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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