SPINT1 and CLDN11

Data Source:
BioGRID (two hybrid)

		SPINT1	CLDN11
Description		serine peptidase inhibitor, Kunitz type 1	claudin 11
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Extracellular Exosome	Lipid Droplet Neurofilament Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Cell Junction Axon Basal Part Of Cell Tight Junction
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Neural Tube Closure Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Positive Regulation Of Glial Cell Differentiation Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Cellular Response To BMP Stimulus Negative Regulation Of Neural Precursor Cell Proliferation	Cell Adhesion Spermatogenesis Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Tight Junction Assembly
Pathways		MET Receptor Activation Signaling by MST1	Tight junction interactions
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Malaria ( 31844061) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)	Blood glucose levels ( 31928498) Monocyte chemoattractant protein-1 (red blood cell fatty acid level interaction) ( 28820441) Prostate cancer ( 21743467)
Interacting Genes		23 interacting genes: ADAM33 AGR3 CLDN11 CLEC7A FAM3C HGFAC HMGB1 KRTAP1-3 MAL NLGN3 SLC38A7 SMCO4 ST14 TENT5A TF TMEM109 TMEM190 TMEM97 TSPAN33 UBQLN2 UBQLN4 UPK1B VAMP5	12 interacting genes: AMIGO1 C16orf54 FNDC9 KLRC1 SHISA3 SMIM3 SPINT1 TMEM80 TNFSF14 TSPAN3 TSPAN4 ZP3
Entrez ID		6692	5010
HPRD ID		05494	03207
Ensembl ID		ENSG00000166145	ENSG00000013297
Uniprot IDs		O43278	O75508
PDB IDs		1YC0 2MSX 4ISL 4ISN 4ISO 5EZD 5H7V
Enriched GO Terms of Interacting Partners?
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