SNX2 and LAMC1

Data Source:
BioGRID (two hybrid)

		SNX2	LAMC1
Description		sorting nexin 2	laminin subunit gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Protein-containing Complex	Extracellular Region Basement Membrane Laminin-1 Complex Extracellular Space Endoplasmic Reticulum Lumen Laminin-10 Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Extracellular Matrix Structural Constituent Extracellular Matrix Constituent Conferring Elasticity
	Biological Process	Intracellular Protein Transport Endocytosis Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis	Cell Adhesion Endoderm Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Maintenance Of Blood-brain Barrier Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Epithelial Cell Proliferation Protein-containing Complex Assembly
Pathways		Golgi Associated Vesicle Biogenesis	Degradation of the extracellular matrix Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			Lanoteplase
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308) Plateletcrit ( 32888494) Subcortical volume (MOSTest) ( 32665545)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 29875488) Clozapine-induced agranulocytosis ( 25187353) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 30224653) Fuchs's corneal dystrophy ( 28358029) HDL cholesterol levels ( 32203549) Height ( 31562340) Hemoglobin ( 32888494) Hypertriglyceridemia ( 27599772) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463)
Interacting Genes		28 interacting genes: ACVR1B ACVR2B ARL6IP1 C1orf122 CENPQ CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET MTIF3 NFYC PAK6 PDGFRA PDGFRB PLIN3 PNKP SNX1 SNX32 SNX4 SNX5 SNX6 TMEM239 YIF1A ZNF202	14 interacting genes: ANTXR2 APP ATF7IP CENPU LAMA5 NID1 NID2 PSMC5 SNAPIN SNX2 SRPK1 TANK UBC WASHC3
Entrez ID		6643	3915
HPRD ID		09332	01030
Ensembl ID		ENSG00000205302	ENSG00000135862
Uniprot IDs		O60749	P11047 Q6NVY8
PDB IDs			5XAU
Enriched GO Terms of Interacting Partners?
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