SMPD1 and ANXA4

Data Source:
BioGRID (two hybrid)

		SMPD1	ANXA4
Description		sphingomyelin phosphodiesterase 1	annexin A4
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GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds Acid Sphingomyelin Phosphodiesterase Activity	Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding
	Biological Process	Plasma Membrane Repair Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Glycosphingolipid Metabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Positive Regulation Of Protein Dephosphorylation Wound Healing Response To Cocaine Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Endocytosis Ceramide Biosynthetic Process Viral Entry Into Host Cell Response To Interleukin-1 Cellular Response To Calcium Ion	Regulation Of Transcription By RNA Polymerase II Signal Transduction Notch Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-8 Production Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity
Pathways		Glycosphingolipid metabolism
Drugs		Amlodipine Chlorpromazine Desipramine Medical Cannabis	Fluocinolone acetonide Copper
Diseases		Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Malaria ( 31844061) Neurological blood protein biomarker levels ( 31320639)	Atrial fibrillation ( 28416818 30061737) Palmitoleic acid (16:1n-7) levels ( 23362303)
Interacting Genes		6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2	8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5
Entrez ID		6609	307
HPRD ID		06353	00112
Ensembl ID		ENSG00000166311	ENSG00000196975
Uniprot IDs		E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0	P09525 Q6LES2 Q6P452
PDB IDs		5I81 5I85 5I8R 5JG8	2ZOC
Enriched GO Terms of Interacting Partners?
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