BMP5 and NOG

Data Source:
HPRD (in vivo)

		BMP5	NOG
Description		bone morphogenetic protein 5	noggin
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Extracellular Space Vesicle	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity BMP Receptor Binding	Protein Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Skeletal System Development Ossification Endocardial Cushion Formation Type B Pancreatic Cell Development Pericardium Morphogenesis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Steroid Biosynthetic Process Neural Fold Elevation Formation BMP Signaling Pathway Hindbrain Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Pharyngeal System Development SMAD Protein Signal Transduction Cardiac Septum Morphogenesis Chorio-allantoic Fusion Heart Trabecula Morphogenesis Negative Regulation Of Mononuclear Cell Migration Positive Regulation Of Dendrite Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Allantois Development Negative Regulation Of Cortisol Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Osteoblast Differentiation In Utero Embryonic Development Endoderm Formation Mesoderm Formation Epithelial To Mesenchymal Transition Neural Plate Morphogenesis Neural Tube Closure Membranous Septum Morphogenesis Outflow Tract Morphogenesis Endocardial Cushion Morphogenesis Ventricular Compact Myocardium Morphogenesis Nervous System Development Motor Neuron Axon Guidance Dorsal/ventral Pattern Formation Positive Regulation Of Gene Expression Spinal Cord Development Cell Differentiation In Hindbrain Pituitary Gland Development Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Wound Healing Middle Ear Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Notochord Morphogenesis Embryonic Skeletal System Development Negative Regulation Of Astrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Atrial Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Muscle Cell Proliferation Limb Development Embryonic Skeletal Joint Morphogenesis Negative Regulation Of Cytokine Activity Face Morphogenesis Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ventricular Septum Morphogenesis Lung Morphogenesis Prostatic Bud Formation Ureteric Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Cartilage Development Somite Development BMP Signaling Pathway Involved In Heart Development Heart Trabecula Morphogenesis Pharyngeal Arch Artery Morphogenesis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Glomerulus Development Negative Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Negative Regulation Of Apoptotic Signaling Pathway
Pathways			Signaling by BMP
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Tarsal-carpal coalition syndrome Stapes ankylosis with broad thumb and toes Other brachydactylies, including: Proximal symphalangism; Multiple synostosis syndrome
GWAS		Colorectal cancer or advanced adenoma ( 30510241) Heel bone mineral density ( 30598549 28869591) Lean body mass ( 28552196) Zinc levels ( 26025379)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 29875488) Celiac disease ( 23936387) Cleft lip with or without cleft palate ( 28054174) Height ( 20881960 31562340 18391951) Metabolite levels ( 23823483) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 20023658) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		5 interacting genes: BMPR1A CHRDL2 FST MEOX2 NOG	4 interacting genes: BMP2 BMP4 BMP5 BMP7
Entrez ID		653	9241
HPRD ID		00210	04291
Ensembl ID		ENSG00000112175	ENSG00000183691
Uniprot IDs		A8K694 M9VUD0 P22003	Q13253
PDB IDs			1M4U
Enriched GO Terms of Interacting Partners?
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