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SKP2 and PSMD9
Data Source:
BioGRID
(fluorescent resonance energy transfer)
SKP2
PSMD9
Description
S-phase kinase associated protein 2
proteasome 26S subunit, non-ATPase 9
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Molecular Function
Protein Binding
Identical Protein Binding
Transcription Coactivator Activity
Protein Binding
BHLH Transcription Factor Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Viral Process
Protein Deubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Innate Immune Response
Defense Response To Virus
Regulation Of Cell Cycle
Protein K48-linked Ubiquitination
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Insulin Secretion
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Secretion
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Proteasome Regulatory Particle Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Birth weight (
31043758
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Red cell distribution width (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
24026423
)
Red blood cell count (
32888494
)
Urinary metabolites (H-NMR features) (
24586186
)
Interacting Genes
64 interacting genes:
AKT1
BRAP
BRCA1
BTG1
BTG2
CCNA2
CCNE1
CCNT1
CDC14B
CDC34
CDH1
CDK2
CDK9
CDKN1A
CDKN1B
CDKN1C
CDT1
CEBPA
CHKA
CKS1B
CKS1BP7
CUL1
CUL4A
DDB1
DUSP1
E2F1
ELF4
EP300
ESR1
FZR1
GPS1
KPNA1
KPNA6
MEF2D
MTOR
MYB
MYBL2
MYC
NLK
ORC1
PAX8
PDCD4
PFDN1
PIM1
POLR2A
PSMD9
RAG2
RB1
RBL2
RND3
SIRT4
SIRT6
SKP1
SLC9A3R1
SMAD4
SQSTM1
TAL1
TCF3
TRIM21
UBB
VHL
WEE1
YWHAB
YY1
20 interacting genes:
AHCYL1
BANP
BRCA1
CCDC136
CEP85L
CKS1B
CSH1
ELSPBP1
MEOX2
NCKIPSD
PSMC3
PSMC6
RIN3
SKP2
TCF3
TNIP2
TRAF2
TRIM39
TRIM42
YY1
Entrez ID
6502
5715
HPRD ID
03256
04394
Ensembl ID
ENSG00000145604
ENSG00000110801
Uniprot IDs
A0A024R069
Q13309
O00233
PDB IDs
1FQV
1FS1
1FS2
1LDK
2ASS
2AST
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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