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SMURF2 and ARHGAP5
Data Source:
HPRD
(two hybrid)
SMURF2
ARHGAP5
Description
SMAD specific E3 ubiquitin protein ligase 2
Rho GTPase activating protein 5
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Nuclear Speck
Membrane Raft
Cytoplasm
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Transforming Growth Factor Beta Receptor Binding
Protein Binding
Identical Protein Binding
SMAD Binding
Ubiquitin Protein Ligase Activity
GTPase Activity
GTPase Activator Activity
Protein Binding
GTP Binding
SH2 Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Deubiquitination
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of BMP Signaling Pathway
Ubiquitin-dependent SMAD Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Trophoblast Cell Migration
Cell Adhesion
Rho Protein Signal Transduction
Mammary Gland Development
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Signaling by BMP
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Asymmetric localization of PCP proteins
Degradation of AXIN
Hedgehog 'on' state
Hedgehog 'on' state
Ub-specific processing proteases
Regulation of RUNX3 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Rho GTPase cycle
Drugs
Diseases
GWAS
Cardiac troponin-I levels (
31014085
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Joint mobility (Beighton score) (
27182965
)
Lung function (FEV1/FVC) (
30804560
)
Lung function (FVC) (
30804560
)
Periodontitis (Mean PAL) (
24024966
)
Asthma (
29273806
)
Interacting Genes
91 interacting genes:
ABRAXAS2
ACBD3
ACOX3
AIMP2
ANAPC5
ARHGAP5
ASH2L
AXIN1
BTRC
CANX
CNKSR2
CUEDC1
DAB2
DAZAP2
DGCR2
EGFR
EPHA1
FKBP4
FLNB
FUBP1
GNG2
HDGFL3
ING2
IRF3
IRF8
ITGB1BP1
KLF5
LAPTM5
LATS1
LMNA
MAVS
NEK6
NKIRAS1
NRAS
PDE4B
PPID
PRICKLE1
PRICKLE2
RAB13
RAB14
RAB17
RAB22A
RAB25
RAN
RAP1B
RASD2
RASL12
RHOA
RHOD
RLIM
RNF11
RNF111
RNF2
RNF20
RPS27A
RRAS2
RTN4IP1
RUNX2
RUNX3
SF3A2
SKIL
SMAD1
SMAD2
SMAD3
SMAD5
SMAD6
SMAD7
SMAP1
SNCA
SNRNP70
SOCS6
SPART
SRSF4
TFPI2
TGFBR1
TMEM139
TNPO3
TOP2A
TRAF2
TRAF4
TSSK4
TXNIP
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2L3
USP15
XPO1
YY1
ZBTB44
11 interacting genes:
ADRB2
ITGA5
ITGB1
PTK2B
PTPN18
RASA1
RHOA
RND1
RND2
RND3
SMURF2
Entrez ID
64750
394
HPRD ID
06901
04060
Ensembl ID
ENSG00000108854
ENSG00000100852
Uniprot IDs
Q96DE7
Q9HAU4
Q13017
PDB IDs
1ZVD
2DJY
2JQZ
2KXQ
2LTZ
6FX4
2EE4
2EE5
5U4V
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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