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SH3BP2 and HCLS1
Data Source:
BioGRID
(two hybrid)
SH3BP2
HCLS1
Description
SH3 domain binding protein 2
hematopoietic cell-specific Lyn substrate 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Actin Filament
Plasma Membrane
Site Of Polarized Growth
Cortical Actin Cytoskeleton
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
SH3 Domain Binding
RNA Polymerase II Transcription Factor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Actin Filament Binding
Biological Process
Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Filament Polymerization
Erythrocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Negative Regulation Of Leukocyte Apoptotic Process
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Drugs
Diseases
Cherubism
GWAS
Huntington's disease progression (
28642124
)
Multiple sclerosis (
24076602
)
Interacting Genes
31 interacting genes:
ABL1
ARHGAP10
CTTN
DBNL
ERBB2
ERBB3
ERBB4
FGFR1
FLT3
FYN
GRB2
HCLS1
KIT
LAT
LCK
MET
MYO1F
PDLIM7
PLCG1
PLCG2
SH3KBP1
SH3RF1
STAT3
SYK
TF
TNKS2
VAV1
VAV2
VAV3
YWHAQ
ZAP70
24 interacting genes:
ACTA1
ACTR2
ACTR3
BLZF1
CASP3
CD79A
CSNK2A1
FGR
GRB2
HAX1
HS1BP3
IKBKG
LYN
LZTR1
MAP4K1
QKI
SH2D4A
SH3BP2
SSBP3
SYK
TERF1
TRIM29
WAS
ZBTB25
Entrez ID
6452
3059
HPRD ID
03657
03199
Ensembl ID
ENSG00000087266
ENSG00000180353
Uniprot IDs
A0A384N6E5
P78314
P14317
PDB IDs
2CR4
3TWR
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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