COP1 and RB1CC1

Data Source:
BioGRID (protein complementation assay)

		COP1	RB1CC1
Description		COP1 E3 ubiquitin ligase	RB1 inducible coiled-coil 1
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GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Phagophore Assembly Site Autophagosome Membrane Lysosome Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Nuclear Membrane Phagophore Assembly Site Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Kinase Binding Molecular Adaptor Activity
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Autophagosome Assembly Autophagy Of Mitochondrion Liver Development Positive Regulation Of Protein Phosphorylation Autophagy Cell Cycle Heart Development Macroautophagy Regulation Of Macroautophagy Autophagy Of Peroxisome Piecemeal Microautophagy Of The Nucleus Positive Regulation Of Cell Size Positive Regulation Of JNK Cascade Reticulophagy Glycophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation	Macroautophagy
Drugs
Diseases
GWAS			Body size at age 10 ( 32376654) Immunoglobulin light chain (AL) amyloidosis (liver involvement) ( 28679651) Mitochondrial DNA copy number (white blood cells) ( 30704525) Refractive error ( 32231278) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ	33 interacting genes: AZI2 BAP1 BLID COP1 EPSTI1 ERRFI1 EXOC1 GABARAP GABARAPL1 GABARAPL2 GLCE GREB1 HBP1 IL13RA2 IL24 ITIH5 LYPD3 MADD MRC2 NSD3 PSMC3IP PTK2 PTK2B RNF20 SYN1 TAX1BP1 TBKBP1 THRSP UBC UMPS VHL VPS45 WIF1
Entrez ID		64326	9821
HPRD ID		07455	06019
Ensembl ID		ENSG00000143207	ENSG00000023287
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	Q8TDY2
PDB IDs		5HQG 5IGQ	6DCE 6GMA
Enriched GO Terms of Interacting Partners?
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