VSIR and ASGR1

Data Source:
BioGRID (two hybrid)

		VSIR	ASGR1
Description		V-set immunoregulatory receptor	asialoglycoprotein receptor 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Enzyme Binding Identical Protein Binding Endopeptidase Activator Activity	Asialoglycoprotein Receptor Activity Protein Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Gene Expression Positive Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Zymogen Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Collagen Catabolic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Negative Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Receptor-mediated Endocytosis Viral Process Protein N-linked Glycosylation Via Asparagine Cellular Response To Extracellular Stimulus
Pathways			Asparagine N-linked glycosylation
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alkaline phosphatase) ( 22001757) Low density lipoprotein cholesterol levels ( 32154731) Medication use (HMG CoA reductase inhibitors) ( 31015401) Serum alkaline phosphatase levels ( 31666285 29403010)
Interacting Genes		27 interacting genes: APOD ASGR1 ATP6V0C BMP10 C14orf180 CCL4L2 CLEC7A CLRN2 CNIH3 DOLK MS4A13 PLPP6 PLPPR2 PLSCR1 SLC35B1 SLC35B4 SMAD3 SMCO4 TMEM100 TMEM14C TMEM218 TMEM229B TMEM97 TNF TSPAN2 TSPO2 VAMP3	43 interacting genes: AHNAK2 AMIGO1 APH1A APP ASGR2 ATP1B4 BLCAP CERS2 CLDN7 CLEC4G CPLX4 CREB3L1 CYB5R3 DHFR ERGIC3 FAM209A FCGR1A FNDC9 GPX8 HIBADH HIVEP1 HSP90AA1 HSP90B1 IGFBP5 KIR2DL3 LAMTOR5 LEUTX LMNA MCEMP1 NEMP1 NLK PDZK1IP1 RBBP6 RNF19B SAR1A SLC10A1 SLC35C2 SPAG4 SUSD3 TG TMX2 VKORC1 VSIR
Entrez ID		64115	432
HPRD ID		15160	00151
Ensembl ID		ENSG00000107738	ENSG00000141505
Uniprot IDs		Q9H7M9	P07306 Q6FGQ5
PDB IDs		6MVL 6OIL 6U6V	1DV8 5JPV 5JQ1
Enriched GO Terms of Interacting Partners?
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