BGN and JPH3

Data Source:
BioGRID (pull down)

		BGN	JPH3
Description		biglycan	junctophilin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Cell Surface Transport Vesicle Extracellular Matrix Sarcolemma Lysosomal Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Integral Component Of Membrane Junctional Membrane Complex
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Glycosaminoglycan Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance Extracellular Matrix Binding	Molecular_function Protein Binding
	Biological Process	Blood Vessel Remodeling Biological_process Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Organization Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Bone Development Articular Cartilage Development	Learning Memory Exploration Behavior Locomotion Regulation Of Synaptic Plasticity Regulation Of Neuronal Synaptic Plasticity Neuromuscular Process Controlling Balance Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Calcium Ion Transport Into Cytosol
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1
Drugs
Diseases			Core neuroacanthocytosis syndromes, including: Chorea-acanthocytosis (ChAc); McLeod syndrome (MLS); Huntington's disease-like 2 (HDL2); Pantothenate kinase associated neurodegeneration (PKAN)
GWAS			Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Height ( 28552196) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Late-onset Alzheimer's disease ( 27770636) Migraine ( 27182965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Refractive error ( 32231278) Small vessel stroke ( 27997041) Systemic juvenile idiopathic arthritis ( 27927641)
Interacting Genes		17 interacting genes: - APOB APP BMP4 CCN4 COL1A1 COL1A2 COL2A1 COL4A2 DAG1 ELN HSPB2 JPH3 MFAP2 PLA2G1B TGFB1 TNF	7 interacting genes: BGN CCR2 KRTAP10-8 PPP1CA SMAD3 SMO TSHR
Entrez ID		633	57338
HPRD ID		02359	05589
Ensembl ID		ENSG00000182492	ENSG00000154118
Uniprot IDs		B4DNL4 P21810	B4DIC1 F8W9A3 Q8WXH2 Q96HD8
PDB IDs
Enriched GO Terms of Interacting Partners?
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