SCN2A and SCN4B

Data Source:
HPRD (in vivo, in vitro)

		SCN2A	SCN4B
Description		sodium voltage-gated channel alpha subunit 2	sodium voltage-gated channel beta subunit 4
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GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Voltage-gated Sodium Channel Complex Intercalated Disc Intrinsic Component Of Plasma Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential	Sodium Ion Transport Positive Regulation Of Sodium Ion Transport Sodium Ion Transmembrane Transport Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil	Ranolazine Valproic acid Oxcarbazepine Cocaine Zonisamide Brivaracetam Dichlorobenzyl alcohol Fish oil
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome	Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Adult body size ( 32376654) Bipolar disorder ( 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)
Interacting Genes		5 interacting genes: ANK3 ARHGEF10L MPP3 RNF130 SCN4B	2 interacting genes: SCN2A YIF1A
Entrez ID		6326	6330
HPRD ID		03133	09749
Ensembl ID		ENSG00000136531	ENSG00000177098
Uniprot IDs		Q99250	B0YJ93 Q8IWT1
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E	4MZ2 4MZ3 5XAW 6VSV
Enriched GO Terms of Interacting Partners?
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