ATXN7 and PPP1R12C

Data Source:
BioGRID (two hybrid)

		ATXN7	PPP1R12C
Description		ataxin 7	protein phosphatase 1 regulatory subunit 12C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Cytoplasm Cytoskeleton
	Molecular Function	Protein Binding	Enzyme Inhibitor Activity Protein Binding Phosphatase Regulator Activity Protein Kinase Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Signal Transduction Negative Regulation Of Catalytic Activity
Pathways		HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		59 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	23 interacting genes: ATP6V1H ATXN7 BHLHA9 C1orf109 CACNA1A CCDC185 CDC42BPA EHHADH EXOC3 IL16 IMP3 MPRIP MYL2 NOD2 NXF1 PAFAH1B2 PPP1CB RBM17 SMAD3 SPECC1L THOC1 TSFM USHBP1
Entrez ID		6314	54776
HPRD ID		06365	11452
Ensembl ID		ENSG00000163635	ENSG00000125503
Uniprot IDs		O15265 Q9UPD8	Q9BZL4
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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