SAA1 and FPR1

Data Source:
HPRD (in vitro)

		SAA1	FPR1
Description		serum amyloid A1	formyl peptide receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Cytoplasm Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding	G Protein-coupled Receptor Binding Complement Receptor Activity G Protein-coupled Receptor Activity N-formyl Peptide Receptor Activity Scavenger Receptor Binding Protein Binding RAGE Receptor Binding
	Biological Process	Activation Of MAPK Activity Positive Regulation Of Cytokine Production Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-1 Production Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Negative Regulation Of Inflammatory Response	Activation Of MAPK Activity Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Cytokine-mediated Signaling Pathway Neutrophil Degranulation
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Interleukin-10 signaling Neutrophil degranulation
Drugs			Nedocromil
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)	Alopecia areata ( 25608926) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		9 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R LAMA1 SELENOS VKORC1	5 interacting genes: ACTG1 ANXA1 GNAI2 GRK2 SAA1
Entrez ID		6288	2357
HPRD ID		00097	00646
Ensembl ID		ENSG00000173432	ENSG00000171051
Uniprot IDs		P0DJI8	P21462
PDB IDs		4IP8 4IP9 6MST
Enriched GO Terms of Interacting Partners?
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