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S100A8 and TUBA1A
Data Source:
BioGRID
(pull down)
S100A8
TUBA1A
Description
S100 calcium binding protein A8
tubulin alpha 1a
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Plasma Membrane
Secretory Granule Lumen
Intermediate Filament Cytoskeleton
Collagen-containing Extracellular Matrix
Extracellular Exosome
Nucleus
Cytoplasm
Cytosol
Microtubule
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Neuromuscular Junction
Cytoplasmic Ribonucleoprotein Granule
Myelin Sheath
Membrane Raft
Recycling Endosome
Extracellular Exosome
Molecular Function
Calcium Ion Binding
Protein Binding
Microtubule Binding
Zinc Ion Binding
Toll-like Receptor 4 Binding
Calcium-dependent Protein Binding
Arachidonic Acid Binding
RAGE Receptor Binding
GTPase Activity
Structural Molecule Activity
Structural Constituent Of Cytoskeleton
Protein Binding
GTP Binding
Protein Domain Specific Binding
Identical Protein Binding
Biological Process
Cytokine Production
Toll-like Receptor Signaling Pathway
Leukocyte Migration Involved In Inflammatory Response
Acute Inflammatory Response
Chronic Inflammatory Response
Positive Regulation Of Peptide Secretion
Autophagy
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Response To Zinc Ion
Astrocyte Development
Peptidyl-cysteine S-nitrosylation
Antimicrobial Humoral Response
Positive Regulation Of Cell Growth
Neutrophil Chemotaxis
Sequestering Of Zinc Ion
Response To Lipopolysaccharide
Chemokine Production
Autocrine Signaling
Wound Healing
Defense Response To Bacterium
Neutrophil Degranulation
Innate Immune Response
Response To Ethanol
Positive Regulation Of Inflammatory Response
Defense Response To Fungus
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cytoskeleton Organization
Neutrophil Aggregation
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Microtubule-based Process
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cytoskeleton-dependent Intracellular Transport
Regulation Of Synapse Organization
Cell Division
Ciliary Basal Body-plasma Membrane Docking
Pathways
RHO GTPases Activate NADPH Oxidases
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Gap junction assembly
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Prefoldin mediated transfer of substrate to CCT/TriC
Formation of tubulin folding intermediates by CCT/TriC
Post-chaperonin tubulin folding pathway
Recycling pathway of L1
Recycling pathway of L1
Hedgehog 'off' state
Cilium Assembly
Anchoring of the basal body to the plasma membrane
Intraflagellar transport
RHO GTPases activate IQGAPs
RHO GTPases Activate Formins
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
COPI-independent Golgi-to-ER retrograde traffic
Mitotic Prometaphase
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
Carboxyterminal post-translational modifications of tubulin
Carboxyterminal post-translational modifications of tubulin
HCMV Early Events
Assembly and cell surface presentation of NMDA receptors
Activation of AMPK downstream of NMDARs
Aggrephagy
Aggrephagy
EML4 and NUDC in mitotic spindle formation
Sealing of the nuclear envelope (NE) by ESCRT-III
Kinesins
Drugs
Calcium
Zinc
Copper
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Albendazole
Vinblastine
Mebendazole
Epothilone D
Patupilone
CYT997
2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
Artenimol
Phenethyl Isothiocyanate
Colchiceine
Diseases
Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS
Asthma (
31619474
)
Matrix metalloproteinase-8 levels (
29212897
)
Brain morphology (MOSTest) (
32665545
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
Interacting Genes
21 interacting genes:
APP
CDKN1A
CEACAM3
CHGB
ERG28
GDF9
IGSF21
KLC2
LRIF1
NCF2
PDCD11
PPIA
PRMT1
PTEN
RAB17
S100A9
TP53
TUBA1A
TUBA4A
TUBB
UNC119
63 interacting genes:
ANXA7
ARL3
ATXN3
B4GALT1
BTG1
C8orf33
CDKN1A
CDKN2A
CEP20
CLIP1
CNP
CPEB2
CXCR1
CYLD
DAG1
DUSP23
EGFR
EML1
GEMIN7
GRM7
GSK3B
GZMB
HDAC6
HTRA2
KEL
KPNB1
LINC01554
LRRK2
MAP2
MAP7D3
MAPK6
MAPRE1
MAX
MX1
MYC
NFATC1
NUDT3
PAFAH1B1
PLA2G7
S100A8
S100A9
SDC3
SIAH1
SMN1
SNCA
SOCS6
SOCS7
SPART
STARD13
STK11
SYK
TAOK2
TBCB
TIMM17A
TK1
TLN1
TTR
TUBB
UBE2D3
VAV1
VCL
YWHAQ
ZAP70
Entrez ID
6279
7846
HPRD ID
00471
03959
Ensembl ID
ENSG00000143546
ENSG00000167552
Uniprot IDs
P05109
Q71U36
PDB IDs
1MR8
1XK4
4GGF
4XJK
5HLO
5HLV
5W1F
6DS2
5JCO
6J8F
6WSL
7C1M
Enriched GO Terms of Interacting Partners
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