RRM2 and TAF1B

Data Source:
BioGRID (two hybrid)

		RRM2	TAF1B
Description		ribonucleotide reductase regulatory subunit M2	TATA-box binding protein associated factor, RNA polymerase I subunit B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm RNA Polymerase Transcription Factor SL1 Complex Nucleolus RNA Polymerase I Core Factor Complex
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding Protein Binding TBP-class Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Negative Regulation Of G0 To G1 Transition	RNA Polymerase I Preinitiation Complex Assembly Transcription, DNA-templated Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Nucleolar Large RRNA Transcription By RNA Polymerase I Positive Regulation Of Gene Expression, Epigenetic
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	SIRT1 negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Egg allergy (maternal genetic effects) ( 29489655) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Nonsyndromic cleft lip with cleft palate ( 28232668) Prostate cancer ( 23535732)
Interacting Genes		9 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53	27 interacting genes: ACADVL APP CALR EP300 ESR1 H2AC20 H2BC21 H3C1 H4C1 MEOX2 MYC NAPB NEDD4 NEDD4L PGR RRN3 RXRA SRPK1 TAF1A TAF1C TAF1D TBP THAP7 TP53 TRB TRIM24 UBTF
Entrez ID		6241	9014
HPRD ID		01587	05363
Ensembl ID		ENSG00000171848	ENSG00000115750
Uniprot IDs		P31350	Q53T94
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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