RRM2 and RRM2B

Data Source:
HPRD (in vitro)

		RRM2	RRM2B
Description		ribonucleotide reductase regulatory subunit M2	ribonucleotide reductase regulatory TP53 inducible subunit M2B
Image
GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Negative Regulation Of G0 To G1 Transition	DNA Replication DNA Repair Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040	Cladribine
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Blood protein levels ( 30072576 29875488) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)
Interacting Genes		9 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53	8 interacting genes: CDKN1A MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		6241	50484
HPRD ID		01587	05276
Ensembl ID		ENSG00000171848	ENSG00000048392
Uniprot IDs		P31350	Q7LG56
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?