RRM2 and NPBWR2

Data Source:
BioGRID (biochemical)

		RRM2	NPBWR2
Description		ribonucleotide reductase regulatory subunit M2	neuropeptides B and W receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection
	Molecular Function	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Metal Ion Binding	G Protein-coupled Receptor Activity Opioid Receptor Activity Protein Binding Neuropeptide Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Replication Deoxyribonucleotide Biosynthetic Process Nucleobase-containing Small Molecule Interconversion Negative Regulation Of G0 To G1 Transition	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Opioid Receptor Signaling Pathway
Pathways		Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs		Cladribine Imexon Gallium nitrate Motexafin gadolinium GTI 2040
Diseases
GWAS		Kidney function decline traits ( 25493955) Prostate cancer ( 23535732)	Body mass index ( 25673413) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		9 interacting genes: CDH1 CDK1 DNM1L KAT5 PLK3 RRM1 RRM2B SDCBP TP53	18 interacting genes: BOLL CYSRT1 KPRP KRT31 KRT34 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 KRTAP6-2 NOTCH2NLA NPB NPW PHAF1 PNMA1 PSMA3
Entrez ID		6241	2832
HPRD ID		01587	02841
Ensembl ID		ENSG00000171848	ENSG00000125522
Uniprot IDs		P31350	P48146
PDB IDs		2UW2 3OLJ 3VPM 3VPN 3VPO
Enriched GO Terms of Interacting Partners?
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