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RPS2 and GADD45A
Data Source:
BioGRID
(two hybrid)
RPS2
GADD45A
Description
ribosomal protein S2
growth arrest and DNA damage inducible alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Focal Adhesion
Membrane
Cytosolic Small Ribosomal Subunit
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Molecular Function
RNA Binding
MRNA Binding
Structural Constituent Of Ribosome
Protein Binding
Fibroblast Growth Factor Binding
Enzyme Binding
Cadherin Binding
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein N-terminus Binding
Promoter-specific Chromatin Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
RRNA Processing
Translation
Translational Initiation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKKK Activity
DNA Repair
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Centrosome Cycle
Negative Regulation Of Angiogenesis
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Mitotic Cell Cycle Arrest
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
RMTs methylate histone arginines
rRNA modification in the nucleus and cytosol
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Protein methylation
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FOXO-mediated transcription of cell cycle genes
Drugs
Copper
Diseases
GWAS
Atrial fibrillation (
29892015
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Bone mineral density (hip) (
30172743
)
Mean corpuscular volume (
29403010
)
Offspring birth weight (
31043758
)
Optic disc area (
28073927
)
Optic disc size (
31809533
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
20 interacting genes:
ANXA2
ANXA7
CDKN1A
DNM2
DUX4
FBXO7
FGF1
FGF3
GABARAPL2
GADD45A
GRB7
GSK3B
MPP3
PRMT3
PTEN
SMN1
SOX5
TK1
TRAF6
YWHAG
69 interacting genes:
ADAP1
ASCC2
AURKA
BAG6
CBY2
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
CNOT9
DCTN2
DNAJC13
EEF1A1
EEF1G
ERG28
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
H1-1
H2AC16
H2BC21
H3-4
H4-16
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
LNX2
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PARVG
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS1
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
Entrez ID
6187
1647
HPRD ID
04690
00528
Ensembl ID
ENSG00000140988
ENSG00000116717
Uniprot IDs
P15880
A5JUZ3
P24522
PDB IDs
4UG0
4V6X
5A2Q
5AJ0
5FLX
5LKS
5OA3
5T2C
5VYC
6EK0
6G18
6G4S
6G51
6G53
6G5H
6G5I
6IP5
6IP6
6IP8
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6YBD
6YBW
6Z6L
6Z6M
6Z6N
6ZLW
6ZM7
6ZME
6ZMI
6ZMO
6ZMT
6ZMW
6ZN5
6ZOJ
6ZOK
6ZON
6ZP4
6ZVH
6ZVJ
7A09
7K5I
2KG4
Enriched GO Terms of Interacting Partners
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