RPL7A and MKNK2

Data Source:
BioGRID (two hybrid)

		RPL7A	MKNK2
Description		ribosomal protein L7a	MAPK interacting serine/threonine kinase 2
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Focal Adhesion Membrane Cytosolic Large Ribosomal Subunit Polysomal Ribosome Synapse	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding Cadherin Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of LSU-rRNA Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription	Regulation Of Translation Protein Phosphorylation Cell Surface Receptor Signaling Pathway Peptidyl-serine Phosphorylation Hemopoiesis Intracellular Signal Transduction Protein Autophosphorylation Cellular Response To Arsenic-containing Substance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Fostamatinib
Diseases
GWAS		Blood protein levels ( 28240269) Malaria ( 31844061)	Nonsyndromic cleft lip with or without cleft palate ( 28087736)
Interacting Genes		8 interacting genes: CCDC47 CTBP2 DUX4 MKNK2 POLR2M SGO1 SOCS3 STAU1	13 interacting genes: CUL2 EIF4E EIF4G1 ESR1 ESR2 MAPK1 MAPK14 MAPK8 MESD PSMA1 RBX1 RPL7A VBP1
Entrez ID		6130	2872
HPRD ID		01712	05459
Ensembl ID		ENSG00000148303	ENSG00000099875
Uniprot IDs		P62424	B3KS07 Q9HBH9
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO	2AC3 2AC5 2HW7 6CJ5 6CJE 6CJH 6CJW 6CJY 6CK3 6CK6 6CKI 6JLR
Enriched GO Terms of Interacting Partners?
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