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RNF2 and PHB2
Data Source:
BioGRID
(affinity chromatography technology, two hybrid, affinity chromatography technology)
RNF2
PHB2
Description
ring finger protein 2
prohibitin 2
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Euchromatin
Sex Chromatin
Nucleus
Nucleoplasm
Nuclear Body
PcG Protein Complex
PRC1 Complex
MLL1 Complex
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Plasma Membrane
Cell Surface
Postsynaptic Density
Nuclear Matrix
Axon
Protein-containing Complex
Mitochondrial Prohibitin Complex
Presynaptic Active Zone
Cell Periphery
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
RING-like Zinc Finger Domain Binding
Protein Binding
Protein C-terminus Binding
Estrogen Receptor Binding
Amide Binding
Identical Protein Binding
Protein Homodimerization Activity
Sphingolipid Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Mitotic Cell Cycle
Gastrulation With Mouth Forming Second
Germ Cell Development
Anterior/posterior Axis Specification
Gene Expression
Histone H2A Monoubiquitination
Histone H2A-K119 Monoubiquitination
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of G0 To G1 Transition
Activation Of MAPK Activity
Mitophagy
Immunoglobulin Production
Protein Import Into Nucleus
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Sister Chromatid Cohesion
Activation Of Phospholipase C Activity
Response To Wounding
Cell Migration
CD40 Signaling Pathway
Regulation Of Complement Activation
Positive Regulation Of Exit From Mitosis
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Induction By Virus Of Host Autophagy
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Mammary Gland Branching Involved In Thelarche
Mammary Gland Alveolus Development
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Hypoxia
Antiviral Innate Immune Response
Regulation Of Cardiolipin Metabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cytochrome-c Oxidase Activity
Activation Of Protein Kinase C Activity
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Transcriptional Regulation by E2F6
Processing of SMDT1
Drugs
Capsaicin
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Clopidogrel active metabolite levels (
28207573
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Obesity-related traits (
23251661
)
Glycated hemoglobin levels (
28898252
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Interacting Genes
59 interacting genes:
ABCB1
AMBRA1
AUTS2
BAALC
BMI1
CASP3
CASP9
CBX2
CBX4
DYSF
ERG
H2AC18
H2AC20
H2AC4
H3-4
KAT8
KMT2A
MBD1
MTNR1A
OTUD6A
PCGF1
PCGF2
PCGF3
PCGF6
PGP
PHB2
PHC1
PHC2
PLK1
PSMC4
RING1
RRM1
RYBP
SIK1
SMURF2
SSX2
TARDBP
TFCP2
TSC22D2
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2H
UBE2J1
UBE2K
UBE2L3
UBE2U
UBE2V1
UBE2V2
UBE2W
USP11
USP19
WASHC1
YAF2
21 interacting genes:
AFP
AKT1
CDC42
ESR1
EZH2
FHL2
HDAC1
HDAC2
HDAC3
HDAC5
MEF2A
MYOD1
NR2F1
NR2F2
PPARG
PRKCA
PTEN
PTMA
RNF2
TEAD3
UPF2
Entrez ID
6045
11331
HPRD ID
07028
17843
Ensembl ID
ENSG00000121481
ENSG00000215021
Uniprot IDs
Q99496
Q99623
PDB IDs
2H0D
3GS2
3H8H
3IXS
3RPG
4R8P
4S3O
6IQE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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